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• W53956213 abstract "As early as 1913 Oppenheimer reported that the toxic effects of digitoxin on the isolated frog heart were considerably attenuated when the glycoside was dissolved in serum rather than in Ringer’s solution. He suggested that digitoxin is partially bound to a constituent of serum. About 20 years later Hoekstra (1931) and Brucke (1934) considered this problem again and demonstrated a binding of digitoxin when various proteins were added to the perfusion medium of isolated frog heart preparations. Further studies carried out by Lendle and Pusch (1935) and Haarmann et al. (1940 a, b) showed the first evidence of albumin being the binding protein in serum. The albumin binding of digitoxin was confirmed by the work of Fawaz and Farah (1944), Farah (1945), and Rothlin and Kallenberger (1950). The first extensive quantitative study on the binding of cardiac glycosides to human plasma proteins was presented by Scholtan et al. (1966) and by Lukas and DeMartino (1969)." @default.
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• W53956213 date "1981-01-01" @default.
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• W53956213 title "Plasma Protein Binding of Cardiac Glycosides" @default.
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• W53956213 doi "https://doi.org/10.1007/978-3-642-68166-0_5" @default.
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