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- W53991744 abstract "Glomerulopathy is a hallmark of diabetic nephropathy (DN), the leading cause of end-stage renal disease (ESRD) in the US. Glomerulopathy is associated with imbalance of signaling cascades regulated by transforming growth factor-beta (TGFβ), contributing to loss of podocytes and albuminuria. MicroRNAs (miRNAs) regulate cellular functions through modulation of signaling cascades via feed-forward loops. To identify miRNAs that regulate initiation and development of human DN, we associated miRNA expression with albuminuria in micro-dissected glomeruli of 26 American Indian patients exhibiting clinically early stages of DN. Twenty out of 377 miRNAs exhibited significant correlation with urine albumin-to-creatinine ratio (ACR) (R>0.6; P<0.0001); of those, miR-21 was highly abundant and also exhibited significant correlation with ACR in a second cohort (n=22). miR-21 is regulated by TGFβ1, which is increased in glomeruli of patients with DN. miR-21-deficient TGFβ1 transgenic mice exhibit increased proteinuria and glomerular extracellular matrix" @default.
- W53991744 created "2016-06-24" @default.
- W53991744 creator A5080868611 @default.
- W53991744 date "2013-01-01" @default.
- W53991744 modified "2023-10-05" @default.
- W53991744 title "MicroRNA in Diabetic and TGFbeta-Related Renal Glomerulopathy." @default.
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