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- W54122913 abstract "Abstract Vitamin C is an essential nutrient for living organisms to protect from oxidative stress. In addition, It shows potent anti-tumor activity through the enhancement of immune system. However, there are few reports regarding the direct cytotoxic activity on tumor cells and its related mechanisms. Therefore, we investigated the direct cytotoxic activity of vitamin C on tumor cells especially through the regulation of SIRT1. Since It is generally known that the activity of SIRT1, a NAD-dependent deacetylase, is related with the survival and proliferation of tumor cells, we have first investigated whether vitamin C shows an anti-tumor effect through the regulation of SIRT1 activity in HCT116s. As a result, we found that extensive apoptosis is occurred in HCT116 in company with the suppression of SIRT1 mRNA expression by the treatment of vitamin C. Even though it is known that SIRT1 expression is regulated by p53, we could not find any differences between p53 wild type HCT116 and p53 null type HCT116. To clarify the direct regulatory effect of vitamin C on SIRT1 activity, we examined the change of phosphorylation on SIRT1 after treatment of vitamin C. We observed that vitamin C suppressed the phosphorylation of SIRT1 on the both of ser27 and ser47 residues. Taken together, our data suggest that vitamin C induces apoptosis in HCT116 via the down-regulation of SIRT1 expression and suppression of its phosphorylation." @default.
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- W54122913 date "2011-04-01" @default.
- W54122913 modified "2023-09-26" @default.
- W54122913 title "The pro-apoptotic effect of vitamin C on colon cancer cell lines, HCT116 via the regulation of SIRT1 expression (165.11)" @default.
- W54122913 doi "https://doi.org/10.4049/jimmunol.186.supp.165.11" @default.
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