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- W54146435 abstract "When patients cannot provide responses to health-related quality-of-life (HRQOL) measures in clinical trials, family or friends may be asked to respond. We present a simple, comprehensive method for assessing agreement between patients with head injury and their proxy responders. In contrast to more traditional approaches, this method defines agreement separately for each patient-proxy pair, and compares HRQOL profiles along three dimensions-level, or the average of the ratings; scatter, or the variability in the ratings; and shape, or the ranks of the ratings. We demonstrate this method in the context of a clinical trial of a treatment for traumatic head injury and compare the results to those obtained using traditional analyses. Options for incorporating proxy responses into clinical trial analyses are discussed." @default.
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- W54146435 date "2002-06-01" @default.
- W54146435 modified "2023-10-16" @default.
- W54146435 title "Measuring agreement between patient and proxy responses to multidimensional health-related quality-of-life measures in clinical trials" @default.
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- W54146435 doi "https://doi.org/10.1016/s0895-4356(02)00392-x" @default.
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