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- W54151027 abstract "Abstract Cyclooxygenase-2 (COX-2) is an enzyme that is inducible by various stimuli such as inflammation. COX-2 expression is increased in a variety of human premalignant and malignant tumors. Celecoxib is a selective inhibitor of COX-2 that have been shown to inhibit cancer cell growth and exert anti-proliferative and pro-apoptotic effects on various cancer cell lines. In this study, we investigated that celecoxib induced apoptosis of lung cancer cell lines, A549 and H460. Increase of apoptotic cells was investigated on celecoxib treated lung cancer cell lines. Cell proliferation was decreased and sub G0 peak was increased. We also observed that celecoxib induced activation of sensor proteins involved in endoplasmic reticulum (ER) stress. Expression of CHOP was induced after treatment of celecoxib on lung cancer cells on time-dependent and dose-dependent manners using RT-PCR and western blot. However, salubrinal, specific inhibitor of eIF-2 alpha phosphatase, did not block CHOP expression and cell death after celecoxib treatment. Paradoxically, celecoxib stimulated COX-2 mRNA and protein on A549, but indomethacin, inhibitor of COX-1 and COX-2 did not induce COX-2 expression. Taken together, we suggest that celecoxib induces apoptosis and ER stress on lung cancer cell line." @default.
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- W54151027 date "2013-05-01" @default.
- W54151027 modified "2023-10-16" @default.
- W54151027 title "Celecoxib induces apoptosis, ER stress, and cyclooxgenase-2 expression on lung cancer cells (P2090)" @default.
- W54151027 doi "https://doi.org/10.4049/jimmunol.190.supp.132.35" @default.
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