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• W54191497 abstract "Research Article1 April 1992free access DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. F. al-Khodairy F. al-Khodairy MRC Cell Mutation Unit, Sussex University, Falmer, UK. Search for more papers by this author A.M. Carr A.M. Carr MRC Cell Mutation Unit, Sussex University, Falmer, UK. Search for more papers by this author F. al-Khodairy F. al-Khodairy MRC Cell Mutation Unit, Sussex University, Falmer, UK. Search for more papers by this author A.M. Carr A.M. Carr MRC Cell Mutation Unit, Sussex University, Falmer, UK. Search for more papers by this author Author Information F. al-Khodairy1 and A.M. Carr1 1MRC Cell Mutation Unit, Sussex University, Falmer, UK. The EMBO Journal (1992)11:1343-1350https://doi.org/10.1002/j.1460-2075.1992.tb05179.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have tested mutants corresponding to 20 DNA repair genes of the fission yeast Schizosaccharomyces pombe for their ability to arrest in G2 after DNA damage. Of the mutants tested, four are profoundly defective in this damage dependent G2 arrest. In addition, these four mutants are highly sensitive to a transient inhibition of DNA synthesis by hydroxyurea. This suggests that the pathway responsible for the recognition of DNA damage and the subsequent mitotic arrest, shares many functions with the mechanism that controls the dependency of mitosis on the completion of S phase. The phenotype of these checkpoint rad mutants in wee mutant backgrounds indicate that the G2 arrest response is mediated either through, or in parallel with, the activity of the cdc2 gene product. Previous ArticleNext Article Volume 11Issue 41 April 1992In this issue RelatedDetailsLoading ..." @default.
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• W54191497 title "DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe." @default.
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• W54191497 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05179.x" @default.
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