Matches in SemOpenAlex for { <https://semopenalex.org/work/W54324690> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W54324690 abstract "The BCR/ABL oncogene is the product of the Philadelphia (Ph) chromosome, the derivative (22q) product of a balanced translocation between chromosomes 9 and 22, t(9;22) (q34.1;q11.21). The BCR/ABL gene fusion is the genetic signature of the hematologic malignancy chronic myeloid leukemia (CML). It is also present in a smaller subset of predominantly adult onset B cell-acute lymphoblastic leukemia (B-ALL), where it confers a poor prognosis when treated with standard chemotherapy. Expression of the BCR/ABL fusion protein results in constitutively activated tyrosine phosphorylation of many cellular proteins with subsequent activation of a large number of cell signaling pathways, ultimately leading to neoplastic transformation. CML has been successfully treated with tyrosine kinase inhibitors such as imatinib, although increasing problems with acquired resistance to the inhibitor has led to alternate related drug therapies. Recently, studies have shown high rates of complete remission with the addition of imatinib to treatment protocols for Ph-positive B-ALL." @default.
- W54324690 created "2016-06-24" @default.
- W54324690 creator A5043587613 @default.
- W54324690 creator A5048109211 @default.
- W54324690 date "2013-01-01" @default.
- W54324690 modified "2023-09-27" @default.
- W54324690 title "BCR/ABL Oncogene" @default.
- W54324690 cites W1585894933 @default.
- W54324690 cites W1979107490 @default.
- W54324690 cites W1998593414 @default.
- W54324690 cites W2012828386 @default.
- W54324690 cites W2020092689 @default.
- W54324690 cites W2021033166 @default.
- W54324690 cites W2028959752 @default.
- W54324690 cites W2100500978 @default.
- W54324690 cites W2123853229 @default.
- W54324690 cites W2125657361 @default.
- W54324690 cites W2140155134 @default.
- W54324690 cites W2275311108 @default.
- W54324690 doi "https://doi.org/10.1016/b978-0-12-374984-0.00144-3" @default.
- W54324690 hasPublicationYear "2013" @default.
- W54324690 type Work @default.
- W54324690 sameAs 54324690 @default.
- W54324690 citedByCount "0" @default.
- W54324690 crossrefType "book-chapter" @default.
- W54324690 hasAuthorship W54324690A5043587613 @default.
- W54324690 hasAuthorship W54324690A5048109211 @default.
- W54324690 hasConcept C104317684 @default.
- W54324690 hasConcept C111829193 @default.
- W54324690 hasConcept C121608353 @default.
- W54324690 hasConcept C125418893 @default.
- W54324690 hasConcept C138626823 @default.
- W54324690 hasConcept C2777583451 @default.
- W54324690 hasConcept C2778729363 @default.
- W54324690 hasConcept C2778904597 @default.
- W54324690 hasConcept C2781018059 @default.
- W54324690 hasConcept C29537977 @default.
- W54324690 hasConcept C42362537 @default.
- W54324690 hasConcept C43907098 @default.
- W54324690 hasConcept C502942594 @default.
- W54324690 hasConcept C54355233 @default.
- W54324690 hasConcept C62478195 @default.
- W54324690 hasConcept C71924100 @default.
- W54324690 hasConcept C86803240 @default.
- W54324690 hasConceptScore W54324690C104317684 @default.
- W54324690 hasConceptScore W54324690C111829193 @default.
- W54324690 hasConceptScore W54324690C121608353 @default.
- W54324690 hasConceptScore W54324690C125418893 @default.
- W54324690 hasConceptScore W54324690C138626823 @default.
- W54324690 hasConceptScore W54324690C2777583451 @default.
- W54324690 hasConceptScore W54324690C2778729363 @default.
- W54324690 hasConceptScore W54324690C2778904597 @default.
- W54324690 hasConceptScore W54324690C2781018059 @default.
- W54324690 hasConceptScore W54324690C29537977 @default.
- W54324690 hasConceptScore W54324690C42362537 @default.
- W54324690 hasConceptScore W54324690C43907098 @default.
- W54324690 hasConceptScore W54324690C502942594 @default.
- W54324690 hasConceptScore W54324690C54355233 @default.
- W54324690 hasConceptScore W54324690C62478195 @default.
- W54324690 hasConceptScore W54324690C71924100 @default.
- W54324690 hasConceptScore W54324690C86803240 @default.
- W54324690 hasLocation W543246901 @default.
- W54324690 hasOpenAccess W54324690 @default.
- W54324690 hasPrimaryLocation W543246901 @default.
- W54324690 hasRelatedWork W14061706 @default.
- W54324690 hasRelatedWork W1580753489 @default.
- W54324690 hasRelatedWork W158808887 @default.
- W54324690 hasRelatedWork W1974370007 @default.
- W54324690 hasRelatedWork W1999545926 @default.
- W54324690 hasRelatedWork W2025416101 @default.
- W54324690 hasRelatedWork W2077484083 @default.
- W54324690 hasRelatedWork W2078008975 @default.
- W54324690 hasRelatedWork W2164450151 @default.
- W54324690 hasRelatedWork W2164738870 @default.
- W54324690 hasRelatedWork W2188003467 @default.
- W54324690 hasRelatedWork W2411760925 @default.
- W54324690 hasRelatedWork W2433962979 @default.
- W54324690 hasRelatedWork W2608962248 @default.
- W54324690 hasRelatedWork W2612215927 @default.
- W54324690 hasRelatedWork W2795887938 @default.
- W54324690 hasRelatedWork W2949191661 @default.
- W54324690 hasRelatedWork W2986539890 @default.
- W54324690 hasRelatedWork W3048556996 @default.
- W54324690 hasRelatedWork W74979015 @default.
- W54324690 isParatext "false" @default.
- W54324690 isRetracted "false" @default.
- W54324690 magId "54324690" @default.
- W54324690 workType "book-chapter" @default.