FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W5434598> ?p ?o ?g. }

• W5434598 endingPage "684" @default.
• W5434598 startingPage "675" @default.
• W5434598 abstract "Rearrangement of the tal-1 gene (also known as SCL or TCL-5) occurs in at least 25% of T-cell acute lymphoblastic leukemias (T-ALLs) and results in the aberrant expression of tal-1 mRNA in the neoplastic cells. Also, tal-1 mRNA is constitutively expressed in erythroid precursors and megakaryocytes. This report describes a direct immunocytochemical study of the distribution and localization of TAL-1 protein in normal human tissues and cell lines using four monoclonal antibodies raised against recombinant TAL-1 proteins. One of these reagents recognizes a protein of 41 kD molecular weight in in vitro- translated TAL-1 proteins, two others recognize proteins of 39 and 41 kD molecular weight, and the fourth antibody also recognizes a TAL-1 protein of 22 kD in addition to the 39- and 41-kD proteins. These anti- TAL-1 antibodies label the nuclei of erythroid precursor cells and megakaryocytes in fetal liver and adult bone marrow. The punctate pattern of nuclear labeling suggests that TAL-1 may comprise part of a novel nuclear structure, similar to that recently found for the PML protein. The nuclei of T cell lines known to express mRNA encoding the full-length TAL-1 protein (eg, CCRF-CEM, RPMI 8402, and Jurkat) are also labeled. A study of normal human tissues (including thymus) showed labeling of smooth muscle, some tissue macrophages, and endothelial cells. TAL-1 protein is undetectable in other cell types. These reagents may play an important role in the diagnosis of T-ALL and could also be used in the context of lymphoma diagnosis on routinely fixed material." @default.
• W5434598 created "2016-06-24" @default.
• W5434598 creator A5027881659 @default.
• W5434598 creator A5035075656 @default.
• W5434598 creator A5044059838 @default.
• W5434598 creator A5051581294 @default.
• W5434598 creator A5051986821 @default.
• W5434598 creator A5071273918 @default.
• W5434598 date "1995-02-01" @default.
• W5434598 modified "2023-10-10" @default.
• W5434598 title "Expression of TAL-1 proteins in human tissues" @default.
• W5434598 cites W122007457 @default.
• W5434598 cites W1576924437 @default.
• W5434598 cites W1718924106 @default.
• W5434598 cites W1725765893 @default.
• W5434598 cites W1852214165 @default.
• W5434598 cites W187113113 @default.
• W5434598 cites W1974870158 @default.
• W5434598 cites W1975647987 @default.
• W5434598 cites W2013046038 @default.
• W5434598 cites W2027226218 @default.
• W5434598 cites W2034224347 @default.
• W5434598 cites W2037856863 @default.
• W5434598 cites W2039555858 @default.
• W5434598 cites W2054091854 @default.
• W5434598 cites W2058577868 @default.
• W5434598 cites W2058838585 @default.
• W5434598 cites W2061656021 @default.
• W5434598 cites W2065301449 @default.
• W5434598 cites W2065652078 @default.
• W5434598 cites W2068133110 @default.
• W5434598 cites W2068446924 @default.
• W5434598 cites W2082670705 @default.
• W5434598 cites W2082797919 @default.
• W5434598 cites W2088692721 @default.
• W5434598 cites W2091830776 @default.
• W5434598 cites W2095075940 @default.
• W5434598 cites W2100837269 @default.
• W5434598 cites W2114599216 @default.
• W5434598 cites W2115073099 @default.
• W5434598 cites W2119121495 @default.
• W5434598 cites W2122467851 @default.
• W5434598 cites W2124314287 @default.
• W5434598 cites W2135464864 @default.
• W5434598 cites W2136855254 @default.
• W5434598 cites W2152095145 @default.
• W5434598 cites W2152972363 @default.
• W5434598 cites W2170258491 @default.
• W5434598 cites W2171046697 @default.
• W5434598 cites W2171204713 @default.
• W5434598 cites W2241970596 @default.
• W5434598 cites W2347068475 @default.
• W5434598 cites W2407977596 @default.
• W5434598 cites W2410498010 @default.
• W5434598 cites W2413098316 @default.
• W5434598 cites W2414377504 @default.
• W5434598 cites W2414627607 @default.
• W5434598 cites W2415597379 @default.
• W5434598 cites W2418442192 @default.
• W5434598 cites W2462390863 @default.
• W5434598 cites W2467916015 @default.
• W5434598 cites W48388848 @default.
• W5434598 cites W93459703 @default.
• W5434598 cites W2188495774 @default.
• W5434598 doi "https://doi.org/10.1182/blood.v85.3.675.bloodjournal853675" @default.
• W5434598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7833471" @default.
• W5434598 hasPublicationYear "1995" @default.
• W5434598 type Work @default.
• W5434598 sameAs 5434598 @default.
• W5434598 citedByCount "110" @default.
• W5434598 countsByYear W54345982012 @default.
• W5434598 countsByYear W54345982013 @default.
• W5434598 countsByYear W54345982014 @default.
• W5434598 countsByYear W54345982016 @default.
• W5434598 countsByYear W54345982019 @default.
• W5434598 countsByYear W54345982020 @default.
• W5434598 countsByYear W54345982022 @default.
• W5434598 countsByYear W54345982023 @default.
• W5434598 crossrefType "journal-article" @default.
• W5434598 hasAuthorship W5434598A5027881659 @default.
• W5434598 hasAuthorship W5434598A5035075656 @default.
• W5434598 hasAuthorship W5434598A5044059838 @default.
• W5434598 hasAuthorship W5434598A5051581294 @default.
• W5434598 hasAuthorship W5434598A5051986821 @default.
• W5434598 hasAuthorship W5434598A5071273918 @default.
• W5434598 hasBestOaLocation W54345981 @default.
• W5434598 hasConcept C104317684 @default.
• W5434598 hasConcept C153911025 @default.
• W5434598 hasConcept C159654299 @default.
• W5434598 hasConcept C179464577 @default.
• W5434598 hasConcept C203014093 @default.
• W5434598 hasConcept C2776090121 @default.
• W5434598 hasConcept C29512474 @default.
• W5434598 hasConcept C54355233 @default.
• W5434598 hasConcept C55493867 @default.
• W5434598 hasConcept C81885089 @default.
• W5434598 hasConcept C86339819 @default.
• W5434598 hasConcept C86803240 @default.

• next