Matches in SemOpenAlex for { <https://semopenalex.org/work/W5440388> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W5440388 endingPage "8" @default.
- W5440388 startingPage "41" @default.
- W5440388 abstract "Mechanisms that underlie the relaxant response to histamine were examined in dog external (a branch of external carotid artery) and internal (a branch of internal carotid artery) ophthalmic arteries (EOA and IOA).Changes in isometric tensions were recorded in helical strips of the arteries with and without the endothelium.Histamine predominantly produced relaxations in EOA and IOA, partially contracted with prostaglandin (PG) F2 alpha. The relaxation of IOA almost was abolished by treatment with cimetidine (10(-5) mol/l), whereas the response of EOA was partially attenuated by treatment with cimetidine or chlorpheniramine (10(-6) mol/l) and was abolished with their combined treatment. Endothelium denudation depressed the relaxation in EOA but did not affect the response of IOA. The response to histamine of EOA was inhibited by treatment with indomethacin (10(-6) mol/l) or tranylcypromine (10(-4) mol/l), a PGI2 synthesis inhibitor, only when the endothelium was present, but additional treatment with chlorpheniramine did not further inhibit relaxation. On the other hand, IOA's response to histamine was not inhibited by indomethacin, despite the presence of endothelium.The histamine-induced relaxation in EOA may be associated with the release of vasodilator PGI2 through the activation of H1 receptors in the endothelium and with the direct action on H2 receptors in smooth muscle, whereas the relaxation in IOA is mediated exclusively by H2 receptors in smooth muscle." @default.
- W5440388 created "2016-06-24" @default.
- W5440388 creator A5003642180 @default.
- W5440388 creator A5058142995 @default.
- W5440388 creator A5063265675 @default.
- W5440388 date "1993-01-01" @default.
- W5440388 modified "2023-10-17" @default.
- W5440388 title "Mechanisms of histamine-induced relaxation in external and internal ophthalmic arteries." @default.
- W5440388 cites W1971493004 @default.
- W5440388 cites W1973619335 @default.
- W5440388 cites W1976145582 @default.
- W5440388 cites W1985328581 @default.
- W5440388 cites W2007176335 @default.
- W5440388 cites W2010976557 @default.
- W5440388 cites W2025863793 @default.
- W5440388 cites W2039416072 @default.
- W5440388 cites W2045612450 @default.
- W5440388 cites W2052242777 @default.
- W5440388 cites W2059799081 @default.
- W5440388 cites W2064862410 @default.
- W5440388 cites W2066902121 @default.
- W5440388 cites W2079949994 @default.
- W5440388 cites W2080407836 @default.
- W5440388 cites W2114253365 @default.
- W5440388 cites W2127067079 @default.
- W5440388 cites W2145828535 @default.
- W5440388 cites W2146743669 @default.
- W5440388 cites W2233026075 @default.
- W5440388 cites W2262851614 @default.
- W5440388 cites W2318150272 @default.
- W5440388 cites W2416079376 @default.
- W5440388 cites W2418498266 @default.
- W5440388 cites W2419595298 @default.
- W5440388 cites W2460496258 @default.
- W5440388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8425838" @default.
- W5440388 hasPublicationYear "1993" @default.
- W5440388 type Work @default.
- W5440388 sameAs 5440388 @default.
- W5440388 citedByCount "7" @default.
- W5440388 countsByYear W54403882013 @default.
- W5440388 crossrefType "journal-article" @default.
- W5440388 hasAuthorship W5440388A5003642180 @default.
- W5440388 hasAuthorship W5440388A5058142995 @default.
- W5440388 hasAuthorship W5440388A5063265675 @default.
- W5440388 hasConcept C10335311 @default.
- W5440388 hasConcept C1122143 @default.
- W5440388 hasConcept C120770815 @default.
- W5440388 hasConcept C126322002 @default.
- W5440388 hasConcept C134018914 @default.
- W5440388 hasConcept C170493617 @default.
- W5440388 hasConcept C185592680 @default.
- W5440388 hasConcept C2776885963 @default.
- W5440388 hasConcept C2776992346 @default.
- W5440388 hasConcept C2777361909 @default.
- W5440388 hasConcept C2780719153 @default.
- W5440388 hasConcept C42219234 @default.
- W5440388 hasConcept C71924100 @default.
- W5440388 hasConceptScore W5440388C10335311 @default.
- W5440388 hasConceptScore W5440388C1122143 @default.
- W5440388 hasConceptScore W5440388C120770815 @default.
- W5440388 hasConceptScore W5440388C126322002 @default.
- W5440388 hasConceptScore W5440388C134018914 @default.
- W5440388 hasConceptScore W5440388C170493617 @default.
- W5440388 hasConceptScore W5440388C185592680 @default.
- W5440388 hasConceptScore W5440388C2776885963 @default.
- W5440388 hasConceptScore W5440388C2776992346 @default.
- W5440388 hasConceptScore W5440388C2777361909 @default.
- W5440388 hasConceptScore W5440388C2780719153 @default.
- W5440388 hasConceptScore W5440388C42219234 @default.
- W5440388 hasConceptScore W5440388C71924100 @default.
- W5440388 hasIssue "1" @default.
- W5440388 hasLocation W54403881 @default.
- W5440388 hasOpenAccess W5440388 @default.
- W5440388 hasPrimaryLocation W54403881 @default.
- W5440388 hasRelatedWork W1968669070 @default.
- W5440388 hasRelatedWork W2002997024 @default.
- W5440388 hasRelatedWork W2010120662 @default.
- W5440388 hasRelatedWork W2044747805 @default.
- W5440388 hasRelatedWork W2138816624 @default.
- W5440388 hasRelatedWork W2146743669 @default.
- W5440388 hasRelatedWork W2326145218 @default.
- W5440388 hasRelatedWork W2396622926 @default.
- W5440388 hasRelatedWork W2415391248 @default.
- W5440388 hasRelatedWork W5440388 @default.
- W5440388 hasVolume "34" @default.
- W5440388 isParatext "false" @default.
- W5440388 isRetracted "false" @default.
- W5440388 magId "5440388" @default.
- W5440388 workType "article" @default.