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- W54497561 abstract "The chapter discusses the increasing dopaminergic activity of cocaine, by binding to the dopamine transporter and inhibiting dopamine uptake. The primary method by which dopamine is deactivated after its release into the synapse is also presented. Auto radiographic studies using cocaine or an analog of cocaine suggest that there are high densities of dopamine transporter labeling in dopaminergic terminal regions. The discussion on cocaine inhibition involving the re-uptake of norepinephrine and serotonin into presynaptic terminals is covered. The primary effect of cocaine is to inhibit dopamine uptake, thereby increasing extracellular dopamine, which remains available to act on pre- and postsynaptic dopamine receptors. Chronic treatment with cocaine has pronounced effects on opioid peptide levels. This chapter illustrates pretreatment with a protein kinase C inhibitor injected into the Ventral Tegmental Area (VTA) that inhibits, both the ability of cocaine to stimulate locomotor activity and the cocaine induced increase in extracellular dopamine in the nucleus accumbens. This suggests that protein kinases may be important in cocaine's effects. The studies highlight considerable evidence that the dopamine transporter and the inhibition of dopamine uptake by cocaine play a major role in the production of cocaine's effects." @default.
- W54497561 created "2016-06-24" @default.
- W54497561 creator A5026011651 @default.
- W54497561 date "1998-01-01" @default.
- W54497561 modified "2023-09-23" @default.
- W54497561 title "Basic Pharmacological Mechanisms of Cocaine" @default.
- W54497561 cites W1488699033 @default.
- W54497561 cites W1537128490 @default.
- W54497561 cites W1829908275 @default.
- W54497561 cites W1832429552 @default.
- W54497561 cites W1883478300 @default.
- W54497561 cites W1893725197 @default.
- W54497561 cites W1907976651 @default.
- W54497561 cites W1916293712 @default.
- W54497561 cites W1924151174 @default.
- W54497561 cites W1938622267 @default.
- W54497561 cites W1939305793 @default.
- W54497561 cites W1951862383 @default.
- W54497561 cites W1961722960 @default.
- W54497561 cites W1964094660 @default.
- W54497561 cites W1964510410 @default.
- W54497561 cites W1964710304 @default.
- W54497561 cites W1964892215 @default.
- W54497561 cites W1967178229 @default.
- W54497561 cites W1968940532 @default.
- W54497561 cites W1969854136 @default.
- W54497561 cites W1971270738 @default.
- W54497561 cites W1972873401 @default.
- W54497561 cites W1972897124 @default.
- W54497561 cites W1973514020 @default.
- W54497561 cites W1974164981 @default.
- W54497561 cites W1976096263 @default.
- W54497561 cites W1976455413 @default.
- W54497561 cites W1977182351 @default.
- W54497561 cites W1977486844 @default.
- W54497561 cites W1978404243 @default.
- W54497561 cites W1979554448 @default.
- W54497561 cites W1980599051 @default.
- W54497561 cites W1980606076 @default.
- W54497561 cites W1980839482 @default.
- W54497561 cites W1983066926 @default.
- W54497561 cites W1988808332 @default.
- W54497561 cites W1990267584 @default.
- W54497561 cites W1991442236 @default.
- W54497561 cites W1991597488 @default.
- W54497561 cites W1991666427 @default.
- W54497561 cites W1993614661 @default.
- W54497561 cites W1994331641 @default.
- W54497561 cites W1994373252 @default.
- W54497561 cites W1998128937 @default.
- W54497561 cites W1998863061 @default.
- W54497561 cites W1999143607 @default.
- W54497561 cites W1999456505 @default.
- W54497561 cites W2000843033 @default.
- W54497561 cites W2002711099 @default.
- W54497561 cites W2008003008 @default.
- W54497561 cites W2011256883 @default.
- W54497561 cites W2012213517 @default.
- W54497561 cites W2014793858 @default.
- W54497561 cites W2016104096 @default.
- W54497561 cites W2017843660 @default.
- W54497561 cites W2018849904 @default.
- W54497561 cites W2021032401 @default.
- W54497561 cites W2021330648 @default.
- W54497561 cites W2023218084 @default.
- W54497561 cites W2025555429 @default.
- W54497561 cites W2026738705 @default.
- W54497561 cites W2027273151 @default.
- W54497561 cites W2027580007 @default.
- W54497561 cites W2028016715 @default.
- W54497561 cites W2029516351 @default.
- W54497561 cites W2030736328 @default.
- W54497561 cites W2031723606 @default.
- W54497561 cites W2033624128 @default.
- W54497561 cites W2035252936 @default.
- W54497561 cites W2037439779 @default.
- W54497561 cites W2038397458 @default.
- W54497561 cites W2040172438 @default.
- W54497561 cites W2042215048 @default.
- W54497561 cites W2045019814 @default.
- W54497561 cites W2045760283 @default.
- W54497561 cites W2046160507 @default.
- W54497561 cites W2049140857 @default.
- W54497561 cites W2050666609 @default.
- W54497561 cites W2051082957 @default.
- W54497561 cites W2053248244 @default.
- W54497561 cites W2054678225 @default.
- W54497561 cites W2058213757 @default.
- W54497561 cites W2062004443 @default.
- W54497561 cites W2062061883 @default.
- W54497561 cites W2062251624 @default.
- W54497561 cites W2063752616 @default.
- W54497561 cites W2063875063 @default.
- W54497561 cites W2065943923 @default.
- W54497561 cites W2066698501 @default.
- W54497561 cites W2067020336 @default.
- W54497561 cites W2069955419 @default.
- W54497561 cites W2070371456 @default.