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- W545502 abstract "The study of hematopoiesis, the generation of blood cell lines throughout life, has provided conceptual, experimental, and therapeutic approaches useful to all stem cell biologists. From a clinical perspective, no other area of stem cell biology has been applied as successfully as has transplantation of bone marrow and cord blood for the treatment of blood diseases (1,2). In the last few years, research in stem cell biology has rapidly expanded to include the study of stem cells from embryonic, fetal, and various adult tissues, engendering novel perspectives regarding the identity, origin, and full therapeutic potential of tissue-specific stem cells (3–6). There are many similarities, as well as differences, between the stem cells that give rise to the nervous system (neuropoiesis) and those that generate the various blood cell lineages (hematopoiesis) (see Table 1). Just as bone marrow gives rise to blood cell lineages throughout life, the “brain marrow” is a proliferative central core of the central nervous system (CNS) comprised of the subependymal zone (SEZ), and other periventricular cell groups, that have the capacity to contribute to neurogenesis throughout life (5,7). In this chapter, we shall examine the theoretical and experimental relationships between bone marrow and brain by reviewing published research that addresses the capacity of adult bone marrow and umbilical cord blood to generate neurons and glia." @default.
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- W545502 date "2003-01-01" @default.
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- W545502 title "The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood" @default.
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- W545502 doi "https://doi.org/10.1007/978-1-59259-298-2_5" @default.
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