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- W54595526 abstract "Over the last decade, cardiac resynchronization therapy (CRT) has emerged as an important treatment modality in patients with heart failure. Primary prevention of mortality with implantable cardioverter-defibrillator (ICD) in patients with ischemic and nonischemic cardiomyopathy and left ventricular dysfunction (ejection fraction [EF] < or =35%) has become the standard of care. A growing number of patients with indications for ICD are also eligible for CRT, receiving resynchronization pacing-defibrillator devices (CRT-D). Randomized clinical trials have provided evidence that cardiac resynchronization therapy is beneficial in heart failure patients and contributes to a significant decrease in heart failure progression on top of administering optimal pharmacological therapy. Currently approved indications for CRT-D include utilizing this treatment modality in heart failure patients with New York Heart Association (NYHA) class III or IV, EF < or =35%, and QRS > or =120 ms. New data from MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy) document that patients with less advanced heart failure (ischemic cardiomyopathy in NYHA class I or II and nonischemic cardiomyopathy class II), EF < or =30%, and QRS > or =130 ms also benefit from CRT. These findings indicate that a more proactive approach should be considered regarding the management of heart failure patients with less advanced disease to decrease progression of heart failure with CRT-D therapy." @default.
- W54595526 created "2016-06-24" @default.
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- W54595526 date "2010-03-01" @default.
- W54595526 modified "2023-09-23" @default.
- W54595526 title "Which patients with chronic heart failure should be referred for CRT‑D implantation? Practical implications of current clinical research" @default.
- W54595526 doi "https://doi.org/10.20452/pamw.897" @default.
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