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• W54665884 abstract "Cardiac neural crest cells (NCCs) are a transient, migratory cell population exclusive to vertebrate embryos. Ablation, transplantation, and lineage-tracing experiments in chick and mouse have demonstrated their essential role in the remodeling of the initially bilateral and symmetric pharyngeal artery pairs into an aortic arch and for the septation of the cardiac outflow tract into the base of the pulmonary artery and aorta. Accordingly, defective cardiac NCC function is a common cause of congenital birth defects. Here, we review our current understanding of cardiac NCC-mediated vascular remodeling and signaling pathways important for this process. We additionally discuss their contribution to the cardiac valves as well as the still contentious role of cardiac NCCs in the development of the myocardium and conductive system of the heart." @default.
• W54665884 created "2016-06-24" @default.
• W54665884 creator A5028928430 @default.
• W54665884 creator A5062668486 @default.
• W54665884 creator A5083333972 @default.
• W54665884 date "2015-01-01" @default.
• W54665884 modified "2023-09-27" @default.
• W54665884 title "Neural Crest Cells in Cardiovascular Development" @default.
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• W54665884 doi "https://doi.org/10.1016/bs.ctdb.2014.11.006" @default.
• W54665884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25662261" @default.
• W54665884 hasPublicationYear "2015" @default.
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