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- W54821009 abstract "Introduction – non-alcoholic fatty liver disease and MCP-1Non-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and diabetes mellitus. It encompasses a clinic-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH).The chemokine monocyte chemoattractant protein (MCP-1) plays an important role in the progression of hepatic inflammation and fibrosis. Increased circulating serum levels have been described in NASH. Here, we aimed to investigate MCP-1 expression in simple hepatic steatosis. Patients and methodsIn a collaboration of three students data of 506 patients, who were referred to the interdisciplinary ultrasound department from January 2008 to January 2009, were collected. After some questions about their medical history and a medical examination, each patient underwent a standardized ultrasound examination. Blood samples were taken and different serum parameters were analyzed, including the chemokine MCP-1.ResultsPatients with ultrasound-diagnosed NAFLD had significantly higher MCP-1 serum levels in comparison to the control group without NAFLD. MCP-1 serum levels correlated significantly with the body-mass index, serum glucose levels and serum transaminases.ConclusionIn comparison to epidemiological studies, only a minority of patients with elevated MCP-1 levels had significant hepatic inflammation. Our data indicate that effects of MCP-1 may even take place in the early phase of hepatic steatosis." @default.
- W54821009 created "2016-06-24" @default.
- W54821009 creator A5011136557 @default.
- W54821009 date "2013-02-27" @default.
- W54821009 modified "2023-09-27" @default.
- W54821009 title "Analysis of systemic monocyte chemoattractant protein-1 levels in patients with and without sonographic evident hepatic steatosis" @default.
- W54821009 hasPublicationYear "2013" @default.
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