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- W54832491 abstract "Haemochromatosis is an inherited disease in which the body absorbs iron at anaccelerated rate, leading to iron overload and oxidative damage. This occurs in majororgans such as the liver, heart and pancreas but may also occur in the brain. The brainhas a high iron requirement and few antioxidants compared to the rest of the body,making it particularly vulnerable to oxidative stress. Brain iron overload has beenimplicated in the pathogenesis and progression of diseases such as Multiple Sclerosis,Parkinson's Disease and Alzheimer's Disease. Case studies have investigated patientswho have both haemochromatosis and altered cognitive functioning, although mosthave involved patients with advanced disease and additional complications, making itdifficult to establish causation. If iron-mediated damage occurs within the brain inpeople with haemochromatosis then it is possible that processes such as memory,learning, attention and information processing speed are affected.These processes aresensitive to brain damage and are commonly influenced by concussion and metabolicdisorders. Separating the primary effects of iron overload from secondary effects suchas anxiety, depression, fatigue and pain is difficult as each impacts on cognition.Many people with haemochromatosis have complained of cognitive problems.However medical staff have attributed these problems to secondary effects of thedisease. No study to date has attempted to investigate the primary effects ofhaemochromatosis on cognitive functioning using comprehensive neuropsychologicaltests and a large patient sample with matched controls." @default.
- W54832491 created "2016-06-24" @default.
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- W54832491 date "2005-01-01" @default.
- W54832491 modified "2023-09-27" @default.
- W54832491 title "Are cognitive processing problems associated with hereditary haemochromatosis" @default.
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