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- W54883783 abstract "Abstract T cells are considered the major contributors to tumor immunity. Because B cells can regulate T cell-mediated immune responses, the role of B cells in tumor immunity was assessed. B cells were depleted in mice with otherwise intact immune systems using CD20-specific mAbs before tumor administration. Subcutaneous B16 melanoma tumors grew to be twice as large in mice lacking B cells compared to control mice. Similarly, the number of visible melanoma metastasis foci on the surface of the lungs was doubled in B cell deficient mice. The numbers of CD4+ and CD8+ effector-memory T cells generated during the anti-tumor response were reduced by 48% and 33%, respectively, in the draining lymph nodes of B cell deficient mice compared to control mice. The induction of IFNγ-secreting CD4+ and CD8+ T cells was impaired by 42% and 34%, respectively, in mice that lacked B cells. Likewise, the induction of TNFα-secreting CD4+ and CD8+ T cells was impaired by 47% and 50%, respectively, in B cell deficient mice. Finally, the proliferation of adoptively-transferred tumor antigen-specific T cells was reduced by 30% in mice lacking B cells. Thereby, tumor growth and metastasis were dramatically enhanced in B cell deficient mice due to a significant reduction of the tumor-specific T cell response. Thus, B cells are required for optimal T cell activation during tumor immunity. Supported by NIH Funding (CA105001 and AI056363)" @default.
- W54883783 created "2016-06-24" @default.
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- W54883783 date "2009-04-01" @default.
- W54883783 modified "2023-09-27" @default.
- W54883783 title "B cells are required for T cell activation during tumor immunity (88.27)" @default.
- W54883783 doi "https://doi.org/10.4049/jimmunol.182.supp.88.27" @default.
- W54883783 hasPublicationYear "2009" @default.
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