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- W54977296 abstract "This chapter presents a treatment approach to good risk germ cell tumor (GCT) patients undertaken at Memorial Sloan-Kettering Cancer Center (MSKCC) over the past 10 years. The stratification of good risk and poor risk evolved from the analysis of pretreatment prognostic factors in 171 patients with advanced testicular germ cell tumors treated with high-dose cisplatin-based chemotherapy from 1975–1981. Variables determined to be independently significant for prognosis were the pretreatment levels of serum tumor markers LDH and HCG and the number of metastatic sites of disease. Prior to 1982, treatment-related mortality occurred in 3–5% of GCT patients and was primarily related to bleomycin pulmonary toxicity and septicemia during neutropaenia. The standard chemotherapy regimen at MSKCC at that time was VAB-6—a multidrug regimen given every four weeks for three cycles. The first MSKCC good risk trial was performed from 1982–1986 and compared VAB-6 to the two-drug regimen of etoposide plus cisplatin. Despite the improved toxicity profile observed with EP, the continued use of cisplatin still resulted in neurological, renal, ontological, and gastrointestinal toxicities." @default.
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- W54977296 date "1994-01-01" @default.
- W54977296 modified "2023-10-17" @default.
- W54977296 title "Good Risk Chemotherapy Trials for Patients with Advanced Germ Cell Tumours: The MSKCC Experience" @default.
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- W54977296 doi "https://doi.org/10.1016/b978-0-08-042198-8.50052-2" @default.
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