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- W54982775 abstract "The blastogenesis of a natural killer (NK) cell population is induced during infection, and a natural defense mechanism preferentially eliminates virus infected cells in vivo. This chapter discusses the proliferation and role of NK cells during viral infection Endogenous NK cells isolated from murine spleens and fractionated on the basis of size by centrifugal elutriation are contained within a limited class of small-to-medium size cells. To directly visualize killing by dividing cells, the single-cell assay of Grimm and Bonavida was combined with autoradiography using Kodak nuclear track emulsion. As it is possible to demonstrate killing by dividing cells, it is of interest to know if conditions that inhibit proliferation in vivo also inhibit the generation of the large NK cells during viral infection. The data indicate that the infection results in the activation of blast NK cells and suggests that this proliferation is tightly regulated." @default.
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- W54982775 date "1982-01-01" @default.
- W54982775 modified "2023-10-03" @default.
- W54982775 title "PROLIFERATION AND ROLE OF NATURAL KILLER CELLS DURING VIRAL INFECTION" @default.
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- W54982775 doi "https://doi.org/10.1016/b978-0-12-341360-4.50079-2" @default.
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