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- W55147056 abstract "In order to reveal properties and effects of glutamate excitation, CA1 pyramidal cells in rat hippocampal slices were impaled and responses to iontophoresis of glutamate onto sensitive spots in the dendrites were analyzed. The glutamate-elicited response consisted of a steady depolarization; its amplitude was dose-dependent. The cellular response to repeated applications of glutamate showed a striking degree of stability. Both dendritic and somatic depolarization, induced by glutamate and current, respectively, elicited similar discharge patterns. The sensitivity to glutamate was highly localized, corresponding to the dendritic tree of a given cell. Short, repeated glutamate pulses did not interfere with an orthodromic test response, whereas longer glutamate ejections often depressed the EPSP. Combined temporal and spatial pairing of glutamate and orthodromic activation was followed by a lasting increase in synaptic efficiency, similar to LTP." @default.
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- W55147056 date "1990-01-01" @default.
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- W55147056 title "Chapter 10 Dendritic excitation by glutamate in CA1 hippocampal cells" @default.
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- W55147056 doi "https://doi.org/10.1016/s0079-6123(08)61246-7" @default.
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