FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W55214380> ?p ?o ?g. }

• W55214380 abstract "ABSTRACT The specific targeting of critical signaling molecules may provide efficient therapies for T-cell acute lymphoblastic leukemia (T-ALL). However target identification and drug development are limited by insufficient numbers of primary T-ALL cells and by their high rate of spontaneous apoptosis. We established a human IL-7-dependent T-ALL cell line – TAIL7 – that maintains several biological and signaling properties of its parental leukemia cells. TAIL7 are pre-T ALL cells that proliferate in response to IL-7 and IL-4. IL-7-stimulation of TAIL7 cells prevents spontaneous in vitro apoptosis, induces cell activation and cell cycle progression. The signaling events triggered by IL-7 include downregulation of p27 kip1 and hyperphosphorylation of Rb. Stimulation of TAIL7 cells by IL-7 leads to phosphorylation of JAK3, STAT5, Akt/PKB and Erk1/2. Importantly, specific blockade of Jak3 by its inhibitor WHI-P131 abrogates the IL-7-mediated proliferation and survival of TAIL7 cells, suggesting that activation of Jak3 is critical for IL-7 responsiveness by these cells. Since TAIL7 cells seem to be a biological surrogate for primary leukemia T-cells, this cell line constitutes a valuable tool for the study of the signaling pathways implicated in T-ALL. Exploitation of this cell line should allow the identification of molecular targets and promote the rational design and validation of anti-leukemia signaling-inhibitors." @default.
• W55214380 created "2016-06-24" @default.
• W55214380 creator A5003981842 @default.
• W55214380 creator A5016169031 @default.
• W55214380 creator A5019128517 @default.
• W55214380 creator A5020549289 @default.
• W55214380 creator A5053524802 @default.
• W55214380 creator A5072321016 @default.
• W55214380 creator A5082614208 @default.
• W55214380 date "2013-01-01" @default.
• W55214380 modified "2023-10-17" @default.
• W55214380 title "discovery in T-ALL An IL-7-dependent human leukemia T-cell line as a valuable tool for drug" @default.
• W55214380 cites W105534366 @default.
• W55214380 cites W1482342778 @default.
• W55214380 cites W1509163238 @default.
• W55214380 cites W1510734879 @default.
• W55214380 cites W159302622 @default.
• W55214380 cites W163953079 @default.
• W55214380 cites W1675716 @default.
• W55214380 cites W1748564991 @default.
• W55214380 cites W1793476185 @default.
• W55214380 cites W1816156148 @default.
• W55214380 cites W1951381722 @default.
• W55214380 cites W1973755084 @default.
• W55214380 cites W1984418041 @default.
• W55214380 cites W1992048975 @default.
• W55214380 cites W1994791278 @default.
• W55214380 cites W2009015060 @default.
• W55214380 cites W2010731453 @default.
• W55214380 cites W2011485783 @default.
• W55214380 cites W2013694352 @default.
• W55214380 cites W2013930294 @default.
• W55214380 cites W2014795514 @default.
• W55214380 cites W2016620454 @default.
• W55214380 cites W2017522755 @default.
• W55214380 cites W2017991495 @default.
• W55214380 cites W2023528999 @default.
• W55214380 cites W2023601085 @default.
• W55214380 cites W2037796429 @default.
• W55214380 cites W2052815740 @default.
• W55214380 cites W2075438156 @default.
• W55214380 cites W2082671778 @default.
• W55214380 cites W2083374779 @default.
• W55214380 cites W2083674819 @default.
• W55214380 cites W2086404440 @default.
• W55214380 cites W2090823859 @default.
• W55214380 cites W2096632716 @default.
• W55214380 cites W2102391679 @default.
• W55214380 cites W2104485296 @default.
• W55214380 cites W2116730357 @default.
• W55214380 cites W2141231618 @default.
• W55214380 cites W2149634034 @default.
• W55214380 cites W2161005241 @default.
• W55214380 cites W2169936576 @default.
• W55214380 cites W2196576584 @default.
• W55214380 cites W2293178816 @default.
• W55214380 cites W2300181711 @default.
• W55214380 cites W2302652104 @default.
• W55214380 cites W2318605753 @default.
• W55214380 cites W2337195173 @default.
• W55214380 cites W2415375510 @default.
• W55214380 cites W2418731850 @default.
• W55214380 cites W2443343209 @default.
• W55214380 cites W3149591292 @default.
• W55214380 cites W34890885 @default.
• W55214380 cites W40631639 @default.
• W55214380 cites W1941685106 @default.
• W55214380 cites W2409862460 @default.
• W55214380 hasPublicationYear "2013" @default.
• W55214380 type Work @default.
• W55214380 sameAs 55214380 @default.
• W55214380 citedByCount "0" @default.
• W55214380 crossrefType "journal-article" @default.
• W55214380 hasAuthorship W55214380A5003981842 @default.
• W55214380 hasAuthorship W55214380A5016169031 @default.
• W55214380 hasAuthorship W55214380A5019128517 @default.
• W55214380 hasAuthorship W55214380A5020549289 @default.
• W55214380 hasAuthorship W55214380A5053524802 @default.
• W55214380 hasAuthorship W55214380A5072321016 @default.
• W55214380 hasAuthorship W55214380A5082614208 @default.
• W55214380 hasConcept C120642132 @default.
• W55214380 hasConcept C179464577 @default.
• W55214380 hasConcept C19317047 @default.
• W55214380 hasConcept C203014093 @default.
• W55214380 hasConcept C2776090121 @default.
• W55214380 hasConcept C2778461978 @default.
• W55214380 hasConcept C2779391668 @default.
• W55214380 hasConcept C502942594 @default.
• W55214380 hasConcept C54355233 @default.
• W55214380 hasConcept C55493867 @default.
• W55214380 hasConcept C62112901 @default.
• W55214380 hasConcept C62478195 @default.
• W55214380 hasConcept C75217442 @default.
• W55214380 hasConcept C81885089 @default.
• W55214380 hasConcept C86803240 @default.
• W55214380 hasConcept C8891405 @default.
• W55214380 hasConcept C95444343 @default.
• W55214380 hasConceptScore W55214380C120642132 @default.
• W55214380 hasConceptScore W55214380C179464577 @default.
• W55214380 hasConceptScore W55214380C19317047 @default.

• next