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- W55222487 abstract "ABSTRACT Many peptides are synthesized and released from the gastrointestinal (GI) tract and the central nervous system (CNS). It is now evident that these peptides influence eating behavior. Peptide YY (PYY) is released postprandially from the gastrointestinal L cells and neuromedin U (NMU) has been found in significant concentrations in both the GI tract and the CNS. Recently NMU has been shown to be a potent anorexigenic peptide and alterations of NMU signaling have been shown to predispose to obesity. Following peripheral administration of PYY3–36, the circulating form of PYY, to mouse, rat, or human, there is marked inhibition of food intake. Obese subjects have lower basal fasting PYY levels and have a smaller postprandial rise. However, obesity does not appear to be associated with resistance to PYY. The effects of NMU and PYY on ingestive behavior and their potential as anti-obesity agents are the focus of this review." @default.
- W55222487 created "2016-06-24" @default.
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- W55222487 date "2006-01-01" @default.
- W55222487 modified "2023-10-16" @default.
- W55222487 title "Peptide YY (PYY) and Neuromedin U (NMU): Effects on Ingestive Behavior" @default.
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- W55222487 doi "https://doi.org/10.1016/b978-012369442-3/50132-x" @default.
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