FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W55223386> ?p ?o ?g. }

• W55223386 abstract "C. albicans is one of the most common fungal pathogens of humans. Important virulence-determining traits include proper cell proliferation and the ability to develop into different cell types, including yeast, pseudohyphae and hyphae. Both of these processes are dependent on environmental cues such as availability and types of nutrients. It is thus important to understand how these cues are sensed and integrated with the machinery that control cell division and development. The TOR pathway plays an important role in mediating environmental conditions in many organisms, and accordingly, TOR kinase is required for cell division and the maintenance of hyphal growth in C. albicans (1). However, the mechanisms by which TOR regulates these processes in the pathogen are not clear. Here, we provide the first characterization of Sfp1p, an orthologue of a major downstream effector of TOR kinase in S. cerevisiae. Deletion of SFP1 in C. albicans resulted in a decrease in cell size, which could be reduced further in the presence of poor carbon source media. The sfp1D/sfp1D cells grew slowly, formed small colonies, and were more sensitive to rapamycin, suggesting that Sfp1p mediates a least part of Tor1p function in C. albicans. Transcription profiles of the deletion strain demonstrated down-regulation of genes involved in ribosome biogenesis, translation, and amino acid synthesis, consistent with a role in the TOR pathway. However, many hyphal-specific genes were upregulated, as well as some genes associated with the opaque cell fate, suggesting additional and novel links with development." @default.
• W55223386 created "2016-06-24" @default.
• W55223386 creator A5064118033 @default.
• W55223386 date "2013-04-01" @default.
• W55223386 modified "2023-09-26" @default.
• W55223386 title "Characterizing the roles of the putative Tor1p effector, Sfp1p, in growth and development of the fungal pathogen Candida albicans" @default.
• W55223386 cites W1012963668 @default.
• W55223386 cites W1972037002 @default.
• W55223386 cites W1975471112 @default.
• W55223386 cites W1975631246 @default.
• W55223386 cites W1994775902 @default.
• W55223386 cites W1995203663 @default.
• W55223386 cites W1995948979 @default.
• W55223386 cites W1999340863 @default.
• W55223386 cites W1999718739 @default.
• W55223386 cites W2005641752 @default.
• W55223386 cites W2007026007 @default.
• W55223386 cites W2008139538 @default.
• W55223386 cites W2015038174 @default.
• W55223386 cites W2030271109 @default.
• W55223386 cites W2036314702 @default.
• W55223386 cites W2041227848 @default.
• W55223386 cites W2049151465 @default.
• W55223386 cites W2049219353 @default.
• W55223386 cites W2052905844 @default.
• W55223386 cites W2057932064 @default.
• W55223386 cites W2063013559 @default.
• W55223386 cites W2064412858 @default.
• W55223386 cites W2073897065 @default.
• W55223386 cites W2078477504 @default.
• W55223386 cites W2081370923 @default.
• W55223386 cites W2083795747 @default.
• W55223386 cites W2086198999 @default.
• W55223386 cites W2088127501 @default.
• W55223386 cites W2096037926 @default.
• W55223386 cites W2099189600 @default.
• W55223386 cites W2103453943 @default.
• W55223386 cites W2109809902 @default.
• W55223386 cites W2110874942 @default.
• W55223386 cites W2112029332 @default.
• W55223386 cites W2112243625 @default.
• W55223386 cites W2117073781 @default.
• W55223386 cites W2124794970 @default.
• W55223386 cites W2125271064 @default.
• W55223386 cites W2126881149 @default.
• W55223386 cites W2128207311 @default.
• W55223386 cites W2128468829 @default.
• W55223386 cites W2133183053 @default.
• W55223386 cites W2134138119 @default.
• W55223386 cites W2139964143 @default.
• W55223386 cites W2141301725 @default.
• W55223386 cites W2142795151 @default.
• W55223386 cites W2143900951 @default.
• W55223386 cites W2144737284 @default.
• W55223386 cites W2150169579 @default.
• W55223386 cites W2151797788 @default.
• W55223386 cites W2152275986 @default.
• W55223386 cites W2155507858 @default.
• W55223386 cites W2155750049 @default.
• W55223386 cites W2161594264 @default.
• W55223386 cites W2161849939 @default.
• W55223386 cites W2165274292 @default.
• W55223386 cites W2165906021 @default.
• W55223386 cites W2166704438 @default.
• W55223386 cites W2222283485 @default.
• W55223386 cites W2517054293 @default.
• W55223386 cites W56813229 @default.
• W55223386 hasPublicationYear "2013" @default.
• W55223386 type Work @default.
• W55223386 sameAs 55223386 @default.
• W55223386 citedByCount "0" @default.
• W55223386 crossrefType "dissertation" @default.
• W55223386 hasAuthorship W55223386A5064118033 @default.
• W55223386 hasConcept C104317684 @default.
• W55223386 hasConcept C145081991 @default.
• W55223386 hasConcept C1491633281 @default.
• W55223386 hasConcept C19843653 @default.
• W55223386 hasConcept C2779419633 @default.
• W55223386 hasConcept C2780917455 @default.
• W55223386 hasConcept C2909523446 @default.
• W55223386 hasConcept C51785407 @default.
• W55223386 hasConcept C54355233 @default.
• W55223386 hasConcept C67705224 @default.
• W55223386 hasConcept C85813293 @default.
• W55223386 hasConcept C86803240 @default.
• W55223386 hasConcept C88478588 @default.
• W55223386 hasConcept C89423630 @default.
• W55223386 hasConcept C90080823 @default.
• W55223386 hasConcept C95444343 @default.
• W55223386 hasConceptScore W55223386C104317684 @default.
• W55223386 hasConceptScore W55223386C145081991 @default.
• W55223386 hasConceptScore W55223386C1491633281 @default.
• W55223386 hasConceptScore W55223386C19843653 @default.
• W55223386 hasConceptScore W55223386C2779419633 @default.
• W55223386 hasConceptScore W55223386C2780917455 @default.
• W55223386 hasConceptScore W55223386C2909523446 @default.
• W55223386 hasConceptScore W55223386C51785407 @default.
• W55223386 hasConceptScore W55223386C54355233 @default.
• W55223386 hasConceptScore W55223386C67705224 @default.
• W55223386 hasConceptScore W55223386C85813293 @default.

• next