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- W55261092 abstract "【Outline of survey】 Lipids, such as cholesterol, are essential components of the body. However, their aberrant accumulation due to an excess intake, etc., causes fatal disorders such as atherosclerotic vascular lesions. Dietary lipids are absorbed from the small intestine, transported throughout the entire body via the liver, and play important roles. Recently, many members of ABC proteins, an ATP-dependent transporter family, were revealed to be involved in lipid circulation in the body and play important roles in lipid homeostasis. However, despite extensive studies, their functions and mechanisms of regulation remain unclear due to difficulties in studying large membrane proteins. We have been intensively investigating ABC proteins for about 20 years after we identified MDR1, the first of the ABC protein genes in eukaryotes. In this project, we will reveal the physiological substances and functions of physiologically important ABC proteins on the basis of our achievements in biochemical studies on them." @default.
- W55261092 created "2016-06-24" @default.
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- W55261092 date "2012-01-01" @default.
- W55261092 modified "2023-09-24" @default.
- W55261092 title "Physiological substances and functions of ABC proteins involved in lipid transport" @default.
- W55261092 hasPublicationYear "2012" @default.
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