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• W55266910 abstract "markdownabstract__Abstract__This thesis investigates the long-term effects of awake glioma surgery in eloquent areas on cognition. The general assumption is that neurological recovery takes place within 3 months; no detailed cognitive follow-up studies have been conducted yet. Glioma patients (N=45) were tested pre- and postoperatively (3 months and 1 year) with a neuropsychological test-protocol assessing language, memory, attention and executive functions. Spontaneous speech was examined pre- and 3 months postoperatively as well as the relation of cognition and emotional factors on global quality of life (QoL). The influence of tumor- and treatment related factors on cognition was also investigated.Impairments were present in all cognitive domains on all test-moments. Permanent improvement postoperatively was found on a memory test. Language was the most sensitive domain for recovery. One language test deteriorated at short-term, and remained impaired at 1 year postoperatively. Two language tests improved between 3 months and 1 year. In addition to language tests, a spontaneous speech analysis was necessary to determine the quality of language production. A case study also underlined the importance of spontaneous speech monitoring intraoperatively to detect disturbances. Global QoL remained relatively stable, with depression as the only predictor for QoL change. Tumor- and treatment related factors were no clear risk-factors for cognitive change. Our results show that cognitive recovery takes longer than 3 months and that language, including spontaneous speech, is a crucial element of cognition to assess. Glioma surgery is possible without inducing major cognitive damage. Patients can be informed about the long-term cognitive prognosis." @default.
• W55266910 created "2016-06-24" @default.
• W55266910 creator A5047880494 @default.
• W55266910 date "2014-06-20" @default.
• W55266910 modified "2023-09-23" @default.
• W55266910 title "Speaking on the Edge: The protection of cognition after glioma surgery in eloquent areas" @default.
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• W55266910 hasPublicationYear "2014" @default.
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