Matches in SemOpenAlex for { <https://semopenalex.org/work/W55292090> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W55292090 abstract "Monitoring of metabolic parameters like O2-consumption and extracellular acidification provides first line information of cell vitality and effects responding to drug addition. For this purpose, a bioelectronic test system based on multiparametric sensor chips has been developed. Cells are directly cultivated on the sensor chips which possess sensors for pH and pO2 measurement and two IDES-sensors for additional detection of cell impedance changes. A fluidic system supplies the cell culture with fresh medium and enables addition and removal of test substances. Sensors are read out in real-time and data is converted to rates of O2-consumption and extracellular acidification. Individual cell cultures can be monitored continuously from hours up to weeks. For experiments, the human cell line MCF-7 was treated with different concentrations of cisplatin (5μM and 10μM) and monitored for three days. For comparison, a WST test and cell count was performed in standard cultures every 24 hours. With the sensor chips first drug mediated effects were detected after 15 hours. In contrast to WST assay or CASY cell count with a series of end point measurements, sensor chips allow detection of drug mediated effects online and in real time." @default.
- W55292090 created "2016-06-24" @default.
- W55292090 creator A5031848209 @default.
- W55292090 creator A5035870267 @default.
- W55292090 creator A5047506006 @default.
- W55292090 creator A5051898663 @default.
- W55292090 creator A5082819333 @default.
- W55292090 date "2009-01-01" @default.
- W55292090 modified "2023-09-24" @default.
- W55292090 title "Sensor chips for multiparametric real time monitoring of cell metabolism and drug response" @default.
- W55292090 cites W2078516930 @default.
- W55292090 cites W2102424336 @default.
- W55292090 cites W2544396297 @default.
- W55292090 doi "https://doi.org/10.1007/978-3-642-03887-7_13" @default.
- W55292090 hasPublicationYear "2009" @default.
- W55292090 type Work @default.
- W55292090 sameAs 55292090 @default.
- W55292090 citedByCount "2" @default.
- W55292090 countsByYear W552920902013 @default.
- W55292090 crossrefType "book-chapter" @default.
- W55292090 hasAuthorship W55292090A5031848209 @default.
- W55292090 hasAuthorship W55292090A5035870267 @default.
- W55292090 hasAuthorship W55292090A5047506006 @default.
- W55292090 hasAuthorship W55292090A5051898663 @default.
- W55292090 hasAuthorship W55292090A5082819333 @default.
- W55292090 hasConcept C136229726 @default.
- W55292090 hasConcept C1491633281 @default.
- W55292090 hasConcept C185592680 @default.
- W55292090 hasConcept C28406088 @default.
- W55292090 hasConcept C54355233 @default.
- W55292090 hasConcept C55493867 @default.
- W55292090 hasConcept C71924100 @default.
- W55292090 hasConcept C79879829 @default.
- W55292090 hasConcept C81885089 @default.
- W55292090 hasConcept C86803240 @default.
- W55292090 hasConceptScore W55292090C136229726 @default.
- W55292090 hasConceptScore W55292090C1491633281 @default.
- W55292090 hasConceptScore W55292090C185592680 @default.
- W55292090 hasConceptScore W55292090C28406088 @default.
- W55292090 hasConceptScore W55292090C54355233 @default.
- W55292090 hasConceptScore W55292090C55493867 @default.
- W55292090 hasConceptScore W55292090C71924100 @default.
- W55292090 hasConceptScore W55292090C79879829 @default.
- W55292090 hasConceptScore W55292090C81885089 @default.
- W55292090 hasConceptScore W55292090C86803240 @default.
- W55292090 hasLocation W552920901 @default.
- W55292090 hasOpenAccess W55292090 @default.
- W55292090 hasPrimaryLocation W552920901 @default.
- W55292090 hasRelatedWork W2016504554 @default.
- W55292090 hasRelatedWork W2061396971 @default.
- W55292090 hasRelatedWork W2091481339 @default.
- W55292090 hasRelatedWork W2092480242 @default.
- W55292090 hasRelatedWork W2876708120 @default.
- W55292090 hasRelatedWork W3001496413 @default.
- W55292090 isParatext "false" @default.
- W55292090 isRetracted "false" @default.
- W55292090 magId "55292090" @default.
- W55292090 workType "book-chapter" @default.