Matches in SemOpenAlex for { <https://semopenalex.org/work/W55360413> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W55360413 endingPage "839" @default.
- W55360413 startingPage "831" @default.
- W55360413 abstract "1. The distribution of distinctive firing modes within the population of CA1 pyramidal cells and their modulation by the extracellular concentration of potassium ([K+]o) were investigated with intracellular recordings in rat hippocampal slices. 2. Pyramidal cells were injected with long (> 250 ms) and brief (3-5 ms) positive current pulses of increasing intensity. In normal [K+]o (3.5 mM), most cells (38 of 46 cells; 83%) were regular spiking neurons (generating accommodating trains of independent action potentials during long depolarizations and a single spike in response to brief stimuli). The remaining pyramidal cells (8 of 46; 17%) displayed differential tendencies to generate stereotyped clusters of action potentials, or bursts, according to which they were grouped into three subsets of endogenous bursters: grade I, bursting only when stimulated with long depolarizing current pulses (6 of 46; 13%); grade II, bursting also in response to brief stimulation (1 of 46; 2%); grade III, bursting also spontaneously even in absence of synaptic transmission (1 of 46; 2%). 3. Raising [K+]o from 3.5 to 7.5 mM (high [K+]o) significantly reduced resting membrane potential and input impedance but did not change the threshold potential for eliciting an action potential. 4. Raising [K+]o to 7.5 mM reversibly converted many regular spiking cells to bursters. Likewise, the burst tendency of normally bursting pyramidal cells increased to a higher grade in high [K+]o. Consequently, the fraction of bursters in high [K+]o (17 of 41 cells; 42%) was approximately 2.5-fold higher than in normal [K+]o and their differential distribution was shifted toward higher grades of bursting.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W55360413 created "2016-06-24" @default.
- W55360413 creator A5009367559 @default.
- W55360413 creator A5034037462 @default.
- W55360413 creator A5045670143 @default.
- W55360413 date "1994-03-01" @default.
- W55360413 modified "2023-10-05" @default.
- W55360413 title "Variant firing patterns in rat hippocampal pyramidal cells modulated by extracellular potassium" @default.
- W55360413 doi "https://doi.org/10.1152/jn.1994.71.3.831" @default.
- W55360413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8201423" @default.
- W55360413 hasPublicationYear "1994" @default.
- W55360413 type Work @default.
- W55360413 sameAs 55360413 @default.
- W55360413 citedByCount "156" @default.
- W55360413 countsByYear W553604132012 @default.
- W55360413 countsByYear W553604132013 @default.
- W55360413 countsByYear W553604132014 @default.
- W55360413 countsByYear W553604132015 @default.
- W55360413 countsByYear W553604132016 @default.
- W55360413 countsByYear W553604132017 @default.
- W55360413 countsByYear W553604132018 @default.
- W55360413 countsByYear W553604132020 @default.
- W55360413 countsByYear W553604132021 @default.
- W55360413 countsByYear W553604132022 @default.
- W55360413 countsByYear W553604132023 @default.
- W55360413 crossrefType "journal-article" @default.
- W55360413 hasAuthorship W55360413A5009367559 @default.
- W55360413 hasAuthorship W55360413A5034037462 @default.
- W55360413 hasAuthorship W55360413A5045670143 @default.
- W55360413 hasConcept C12554922 @default.
- W55360413 hasConcept C148762608 @default.
- W55360413 hasConcept C169760540 @default.
- W55360413 hasConcept C178790620 @default.
- W55360413 hasConcept C181911157 @default.
- W55360413 hasConcept C185263204 @default.
- W55360413 hasConcept C185592680 @default.
- W55360413 hasConcept C195221683 @default.
- W55360413 hasConcept C24998067 @default.
- W55360413 hasConcept C2778437258 @default.
- W55360413 hasConcept C28406088 @default.
- W55360413 hasConcept C2908647359 @default.
- W55360413 hasConcept C4141045 @default.
- W55360413 hasConcept C517785266 @default.
- W55360413 hasConcept C55493867 @default.
- W55360413 hasConcept C71924100 @default.
- W55360413 hasConcept C79879829 @default.
- W55360413 hasConcept C86803240 @default.
- W55360413 hasConcept C99454951 @default.
- W55360413 hasConceptScore W55360413C12554922 @default.
- W55360413 hasConceptScore W55360413C148762608 @default.
- W55360413 hasConceptScore W55360413C169760540 @default.
- W55360413 hasConceptScore W55360413C178790620 @default.
- W55360413 hasConceptScore W55360413C181911157 @default.
- W55360413 hasConceptScore W55360413C185263204 @default.
- W55360413 hasConceptScore W55360413C185592680 @default.
- W55360413 hasConceptScore W55360413C195221683 @default.
- W55360413 hasConceptScore W55360413C24998067 @default.
- W55360413 hasConceptScore W55360413C2778437258 @default.
- W55360413 hasConceptScore W55360413C28406088 @default.
- W55360413 hasConceptScore W55360413C2908647359 @default.
- W55360413 hasConceptScore W55360413C4141045 @default.
- W55360413 hasConceptScore W55360413C517785266 @default.
- W55360413 hasConceptScore W55360413C55493867 @default.
- W55360413 hasConceptScore W55360413C71924100 @default.
- W55360413 hasConceptScore W55360413C79879829 @default.
- W55360413 hasConceptScore W55360413C86803240 @default.
- W55360413 hasConceptScore W55360413C99454951 @default.
- W55360413 hasIssue "3" @default.
- W55360413 hasLocation W553604131 @default.
- W55360413 hasLocation W553604132 @default.
- W55360413 hasOpenAccess W55360413 @default.
- W55360413 hasPrimaryLocation W553604131 @default.
- W55360413 hasRelatedWork W1804687031 @default.
- W55360413 hasRelatedWork W2041771357 @default.
- W55360413 hasRelatedWork W2057759106 @default.
- W55360413 hasRelatedWork W2058853317 @default.
- W55360413 hasRelatedWork W2061598419 @default.
- W55360413 hasRelatedWork W2068406497 @default.
- W55360413 hasRelatedWork W2097710660 @default.
- W55360413 hasRelatedWork W2126000479 @default.
- W55360413 hasRelatedWork W2130509656 @default.
- W55360413 hasRelatedWork W271802534 @default.
- W55360413 hasVolume "71" @default.
- W55360413 isParatext "false" @default.
- W55360413 isRetracted "false" @default.
- W55360413 magId "55360413" @default.
- W55360413 workType "article" @default.