Matches in SemOpenAlex for { <https://semopenalex.org/work/W55408171> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W55408171 endingPage "837" @default.
- W55408171 startingPage "833" @default.
- W55408171 abstract "With density functional theory(DFT) and molecular mechanics method, the catalytic mechanism of silent information regulator(sirtuins) has been investigated. The calculations support the SN2-like reaction of the initial step of the catalysis, and are consistent with experiment results. We further explored the second step of the catalysis and proposed that this step took place in a concerted reaction. In addition, the side chain of Phenylalanine33 may help to shield the glycosidic bond from water and be in a position to protect the developing oxacabenium transition state from hydrolysis. Our results of the calculations support this hypothesis that the phenylalanine33 plays a critical role in the sirtuins biology function. Keywords Sirtuin; NAD + ; p53; Model; Density functional theory Article ID 1005-9040(2010)-05-833-05" @default.
- W55408171 created "2016-06-24" @default.
- W55408171 creator A5035768363 @default.
- W55408171 creator A5046175815 @default.
- W55408171 creator A5058366891 @default.
- W55408171 creator A5069393610 @default.
- W55408171 creator A5069676031 @default.
- W55408171 date "2010-11-26" @default.
- W55408171 modified "2023-09-24" @default.
- W55408171 title "Insight into Reaction Mechanism of Sirtuins via Molecular Simulation and Density Functional Theory Study" @default.
- W55408171 hasPublicationYear "2010" @default.
- W55408171 type Work @default.
- W55408171 sameAs 55408171 @default.
- W55408171 citedByCount "0" @default.
- W55408171 crossrefType "journal-article" @default.
- W55408171 hasAuthorship W55408171A5035768363 @default.
- W55408171 hasAuthorship W55408171A5046175815 @default.
- W55408171 hasAuthorship W55408171A5058366891 @default.
- W55408171 hasAuthorship W55408171A5069393610 @default.
- W55408171 hasAuthorship W55408171A5069676031 @default.
- W55408171 hasConcept C121332964 @default.
- W55408171 hasConcept C12554922 @default.
- W55408171 hasConcept C147597530 @default.
- W55408171 hasConcept C150487720 @default.
- W55408171 hasConcept C152365726 @default.
- W55408171 hasConcept C161790260 @default.
- W55408171 hasConcept C181199279 @default.
- W55408171 hasConcept C185592680 @default.
- W55408171 hasConcept C25057246 @default.
- W55408171 hasConcept C2780561631 @default.
- W55408171 hasConcept C55493867 @default.
- W55408171 hasConcept C59593255 @default.
- W55408171 hasConcept C62520636 @default.
- W55408171 hasConcept C65024703 @default.
- W55408171 hasConcept C71240020 @default.
- W55408171 hasConcept C75520062 @default.
- W55408171 hasConcept C86803240 @default.
- W55408171 hasConcept C89611455 @default.
- W55408171 hasConcept C96765332 @default.
- W55408171 hasConceptScore W55408171C121332964 @default.
- W55408171 hasConceptScore W55408171C12554922 @default.
- W55408171 hasConceptScore W55408171C147597530 @default.
- W55408171 hasConceptScore W55408171C150487720 @default.
- W55408171 hasConceptScore W55408171C152365726 @default.
- W55408171 hasConceptScore W55408171C161790260 @default.
- W55408171 hasConceptScore W55408171C181199279 @default.
- W55408171 hasConceptScore W55408171C185592680 @default.
- W55408171 hasConceptScore W55408171C25057246 @default.
- W55408171 hasConceptScore W55408171C2780561631 @default.
- W55408171 hasConceptScore W55408171C55493867 @default.
- W55408171 hasConceptScore W55408171C59593255 @default.
- W55408171 hasConceptScore W55408171C62520636 @default.
- W55408171 hasConceptScore W55408171C65024703 @default.
- W55408171 hasConceptScore W55408171C71240020 @default.
- W55408171 hasConceptScore W55408171C75520062 @default.
- W55408171 hasConceptScore W55408171C86803240 @default.
- W55408171 hasConceptScore W55408171C89611455 @default.
- W55408171 hasConceptScore W55408171C96765332 @default.
- W55408171 hasIssue "5" @default.
- W55408171 hasLocation W554081711 @default.
- W55408171 hasOpenAccess W55408171 @default.
- W55408171 hasPrimaryLocation W554081711 @default.
- W55408171 hasVolume "26" @default.
- W55408171 isParatext "false" @default.
- W55408171 isRetracted "false" @default.
- W55408171 magId "55408171" @default.
- W55408171 workType "article" @default.