Matches in SemOpenAlex for { <https://semopenalex.org/work/W5544890> ?p ?o ?g. }
- W5544890 abstract "The mitotic checkpoint is a control mechanism that ensures proper microtubule-kinetochore attachment and correct chromosome segregation during mitosis. A defective checkpoint signal can lead to chromosome missegregation and aneuploidy, which can lead to cancer. In this report I will summarize the different mitotic checkpoint proteins and their function in inhibiting metaphase to anaphase transition when defective kinetochore-microtubule attachment occurs. As research has been done in many different model organisms I will mainly focus on the evolutionary conservation of the mitotic checkpoint and its proteins. I conclude that the mitotic checkpoint complex is a well conserved mechanism from yeast to human. Although it seems that every organisms has some specific small differences and that higher eukaryotes need extra mechanisms to regulate the checkpoint, the core idea remains the same. Comparing the results obtained in different organisms also gives new insides in what features of the mitotic checkpoint are not yet well established and need more research." @default.
- W5544890 created "2016-06-24" @default.
- W5544890 creator A5014300575 @default.
- W5544890 date "2010-09-03" @default.
- W5544890 modified "2023-09-26" @default.
- W5544890 title "On evolutionary conservation of mitotic checkpoint signaling" @default.
- W5544890 cites W1508230049 @default.
- W5544890 cites W1535467971 @default.
- W5544890 cites W1540858422 @default.
- W5544890 cites W1549756735 @default.
- W5544890 cites W1834223380 @default.
- W5544890 cites W1867836395 @default.
- W5544890 cites W1880615100 @default.
- W5544890 cites W1896640083 @default.
- W5544890 cites W1927775801 @default.
- W5544890 cites W1934294339 @default.
- W5544890 cites W1937702437 @default.
- W5544890 cites W1939672693 @default.
- W5544890 cites W1961562730 @default.
- W5544890 cites W1963750681 @default.
- W5544890 cites W1964505722 @default.
- W5544890 cites W1965143113 @default.
- W5544890 cites W1965475092 @default.
- W5544890 cites W1966205440 @default.
- W5544890 cites W1966669440 @default.
- W5544890 cites W1966773208 @default.
- W5544890 cites W1967145281 @default.
- W5544890 cites W1969236463 @default.
- W5544890 cites W1969873424 @default.
- W5544890 cites W1973916918 @default.
- W5544890 cites W1974454155 @default.
- W5544890 cites W1978303769 @default.
- W5544890 cites W1980487829 @default.
- W5544890 cites W1980619999 @default.
- W5544890 cites W1980779852 @default.
- W5544890 cites W1982779711 @default.
- W5544890 cites W1991523959 @default.
- W5544890 cites W1994177513 @default.
- W5544890 cites W1996481792 @default.
- W5544890 cites W1996794317 @default.
- W5544890 cites W1996991848 @default.
- W5544890 cites W1997671833 @default.
- W5544890 cites W1997764447 @default.
- W5544890 cites W2001110139 @default.
- W5544890 cites W2004616980 @default.
- W5544890 cites W2005383283 @default.
- W5544890 cites W2006389406 @default.
- W5544890 cites W2006419165 @default.
- W5544890 cites W2007074379 @default.
- W5544890 cites W2007323068 @default.
- W5544890 cites W2007388359 @default.
- W5544890 cites W2007969738 @default.
- W5544890 cites W2008754850 @default.
- W5544890 cites W2009514478 @default.
- W5544890 cites W2010167346 @default.
- W5544890 cites W2011410033 @default.
- W5544890 cites W2012349156 @default.
- W5544890 cites W2013720953 @default.
- W5544890 cites W2015187344 @default.
- W5544890 cites W2015224745 @default.
- W5544890 cites W2015759736 @default.
- W5544890 cites W2015815383 @default.
- W5544890 cites W2016019304 @default.
- W5544890 cites W2016500227 @default.
- W5544890 cites W2017518375 @default.
- W5544890 cites W2017616865 @default.
- W5544890 cites W2018711267 @default.
- W5544890 cites W2020202471 @default.
- W5544890 cites W2021740241 @default.
- W5544890 cites W2022017714 @default.
- W5544890 cites W2022239608 @default.
- W5544890 cites W2022947433 @default.
- W5544890 cites W2029158215 @default.
- W5544890 cites W2029384672 @default.
- W5544890 cites W2030480153 @default.
- W5544890 cites W2032420030 @default.
- W5544890 cites W2033154776 @default.
- W5544890 cites W2034243945 @default.
- W5544890 cites W2036068405 @default.
- W5544890 cites W2037533459 @default.
- W5544890 cites W2037607661 @default.
- W5544890 cites W2039426604 @default.
- W5544890 cites W2040472652 @default.
- W5544890 cites W2042231416 @default.
- W5544890 cites W2043501072 @default.
- W5544890 cites W2045539221 @default.
- W5544890 cites W2048309959 @default.
- W5544890 cites W2048735610 @default.
- W5544890 cites W2048938594 @default.
- W5544890 cites W2048994246 @default.
- W5544890 cites W2050321764 @default.
- W5544890 cites W2051502996 @default.
- W5544890 cites W2051836148 @default.
- W5544890 cites W2054818623 @default.
- W5544890 cites W2055743739 @default.
- W5544890 cites W2055782670 @default.
- W5544890 cites W2057334048 @default.
- W5544890 cites W2061443891 @default.
- W5544890 cites W2062117947 @default.
- W5544890 cites W2063330798 @default.