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• W55509936 abstract "Background The aim of this study was to assess the long-term efficacy and safety of first-line treatment with once-daily saquinavir/ritonavir plus two nucleoside reverse transcriptase inhibitors (NRTIs). Methods A total of 272 antiretroviral-naive patients with a CD4 + T-cell count of 200–350 cells/mm 3 were treated with two NRTIs and saquinavir/ritonavir 1,600/100 mg per day for ≥24 weeks. Patients were followed up every 12 weeks for CD4 + T-cell counts, HIV RNA levels, clinical and laboratory toxicities. Intention-to-treat analyses were used for the first 24 weeks of treatment and as-treated analysis after week 24. Results The median baseline CD4 + T-cell count was 269 cells/mm 3 and HIV RNA was 4.7 log 10 copies/ml. At a median follow-up time of 56 (interquartile range [IQR] 25–113) weeks, 262/272 (96.3%) had HIV RNA <400 copies/ml, with a median HIV RNA decline of -2.89 (IQR 3.31–2.37) log 10 copies/ml ( P<0.001) and a median rise in CD4 + T-cell count of 192 (IQR 117–317) cells ( P<0.001). At weeks 24, 48, 72 and 96, 249/272 (91.5%), 157/164 (95.7%), 113/126 (89.7%) and 84/90 (93.3%) had HIV RNA <400 copies/ml, respectively; at the same time points, 83.8%, 92.7%, 85.7% and 85.6% had HIV RNA <50 copies/ml. Drug-related adverse events were reported in 6.3%. Significant rises in total cholesterol, triglyceride, low-density lipoprotein and high-density lipoprotein were seen. Conclusion First-line highly active antiretroviral therapy with once-daily saquinavir/ritonavir plus two NRTIs showed strong antiviral efficacy." @default.
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• W55509936 date "2007-04-01" @default.
• W55509936 modified "2023-10-16" @default.
• W55509936 title "Long-Term Efficacy and Safety of First-Line Therapy with Once-Daily Saquinavir/Ritonavir" @default.
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• W55509936 doi "https://doi.org/10.1177/135965350801300302" @default.
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