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- W5551561 abstract "Carcinogenic polycyclic aromatic hydrocarbons are metabolized in cells in which they induce biological effects (1,2). A small portion of the metabolites formed are reactive derivatives that bind covalently to cellular macromolecules; this binding process can lead to the induction of biological effects (1). Several lines of evidence (reviewed in 1–4) suggest that the interaction of hydrocarbon metabolites with DNA is involved in the initiation of carcinogenesis in vivo and the induction of mutagenesis in cells in culture. The major DNA-binding metabolites formed from several hydrocarbons in cells in culture and tissues in vivo are dihydrodiol-epoxides, usually at the “bay-region” of the molecule (5–9). Diol epoxides are formed on other regions of some hydrocarbons and are involved in the DNA-binding of these hydrocarbons (10,11)." @default.
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- W5551561 date "1983-01-01" @default.
- W5551561 modified "2023-09-27" @default.
- W5551561 title "Time-Dependent Differences in the Benzo[a]pyrene-DNA Adducts Present in Cell Cultures from Different Species" @default.
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- W5551561 doi "https://doi.org/10.1007/978-1-4684-4400-1_30" @default.
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