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- W55521707 abstract "This half-day workshop presents intermediate topics and hands-on exercises on risk based methodologies for assessing cumulative health risk from exposure to chemical mixtures, including considerations of multiple route exposures and toxicological interactions. Included are limited descriptions of basic concepts, the introduction of cutting edge chemical mixture health risk assessment risk issues, explanation of state-of-the-art methods, and hands on exercises for several important classes of chemical mixtures (e.g., pesticides, metals, drinking water disinfection by-products). Workshop topics include: procedures and definitions for selecting among risk assessment methods; methods for incorporating toxicologic interactions data (weight of evidence for interactions; the interaction-based hazard index); discussions of exposure issues unique to chemical mixtures (e.g., environmental transformations); use of physiologically-based pharmacokinetic modeling of interactions and multiple route exposure assessment; and integrating relative potency factors with response addition for mixtures of chemicals representing similar and dissimilar toxic modes of action. The content of this workshop includes a general overview of chemical mixture health risk assessment data evaluation and procedures, a detailed description of several new methods, and in-depth hands-on exercises with test data sets. Discussions include real world examples, exercise results, issues for application of the procedures, and general questions and comments. Participants are asked to bring a calculator.." @default.
- W55521707 created "2016-06-24" @default.
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- W55521707 date "2005-01-01" @default.
- W55521707 modified "2023-09-25" @default.
- W55521707 title "Methods and Guidance on Health Risk Assessment of Chemical Mixtures" @default.
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