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- W5553764 abstract "Abstract An ameba of the genus Naegleria fowleri, causing fatal meningoencephalitis in a human subject, has been investigated for its sensitivities to 5-fluorouracil (4.75 mg/ml), amphotericin B (0.1 μg/ml) and a combination of 5-fluorouracil (40 μg/ml) and amphotericin B (0.01 μg/ml), respectively (t < 0.001). This combination of two drugs has been compared with that of the standard drug amphotericin B, to produce 50% mortality of pathogenic Naegleria spp Thai strain and Naegleria fowleri (CDC VO3081). This report shows that the IC 50 of the drug combination is significantly lower than the use of amphotericin B and 5-fluorouracil alone (t < 0.001). In conclusion, the combination of the two drugs, 5-fluorouracil and amphotericin B, is highly amebicidal in vitro. Keywords : 5-fluorouracil, pathogenic Naegleria spp" @default.
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- W5553764 date "2002-01-01" @default.
- W5553764 modified "2023-09-23" @default.
- W5553764 title "In Vitro Susceptibility Testing of Pathogenic Naegleria spp Thai Strain to the Drug Combination of 5-fluorouracil and Amphotericin B" @default.
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