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- W55647585 abstract "Abstract Mucosal memory CD8 T cells are characterized by their location at peripheral interfaces and the ability to immediately exhibit effector functions. By contrast, lymphoid memory T cells reside within lymphoid tissues and require further differentiation to become effectors. Both memory subtypes contribute to protective immunity, but the accumulation of mucosal effector memory T cells at pathogen portals forms a central component of protective immunity. The process that drives the compartmentalization and functional differentiation of this memory subset is poorly understood. Here we show that the thymus leukemia (TL) antigen, a ligand for the TCR co-repressor, CD8αα, serves a key role in the molecular mechanism that determines the fate of mucosal CD8αβ+ effector T cells. TL specifically controls the survival of CD8αα+CD8αβ+ effectors, but eliminates CD8αα negative CD8αβ effectors. This TL-CD8αα-mediated process allows the intestinal environment to selectively preserve the fittest effector cells to become mucosal memory T cells that form the first line of immune protection." @default.
- W55647585 created "2016-06-24" @default.
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- W55647585 date "2009-04-01" @default.
- W55647585 modified "2023-09-26" @default.
- W55647585 title "Tissue-Specific Cues Direct Fate Decisions of Mucosal Memory T Cells (39.21)" @default.
- W55647585 doi "https://doi.org/10.4049/jimmunol.182.supp.39.21" @default.
- W55647585 hasPublicationYear "2009" @default.
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