Matches in SemOpenAlex for { <https://semopenalex.org/work/W55697788> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W55697788 endingPage "028" @default.
- W55697788 startingPage "023" @default.
- W55697788 abstract "Two polyethylene glycol (PEG)-modified interferons are approved for the treatment of chronic hepatitis C. The pharmocokinetic properties of the branched 40 kDa pegylated interferon alfa-2a differ from the linear 12 kDa pegylated interferon alfa-2b. The absorption half-life of standard interferon alfa is 2.3 hours, while absorption half-lives for peginterferon alfa-2a and alfa-2b are 50 hours and 4.6 hours, respectively. The volume of distribution for peginterferon alfa-2a is considerably restricted, while the volume of distribution for peginterferon alfa-2b is only approximately 30% lower than that for conventional interferon. Because of its large size, the 40 kD peginterferon alfa-2a has a more than 100-fold reduction in renal clearance compared with conventional interferon alfa. Clearance of peginterferon alfa-2b is about one-tenth that of unmodified interferon alfa. Although data are limited, both drugs appear to show differences in the initial viral decay pattern in patients with chronic hepatitis C. However, it remains unknown whether these differences in the initial viral decline predict differences in the primary clinical endpoint, sustained virological response." @default.
- W55697788 created "2016-06-24" @default.
- W55697788 date "2003-01-01" @default.
- W55697788 modified "2023-10-14" @default.
- W55697788 title "Pharmacokinetics of Peginterferons" @default.
- W55697788 doi "https://doi.org/10.1055/s-2003-41631" @default.
- W55697788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12934165" @default.
- W55697788 hasPublicationYear "2003" @default.
- W55697788 type Work @default.
- W55697788 sameAs 55697788 @default.
- W55697788 citedByCount "95" @default.
- W55697788 countsByYear W556977882012 @default.
- W55697788 countsByYear W556977882013 @default.
- W55697788 countsByYear W556977882014 @default.
- W55697788 countsByYear W556977882015 @default.
- W55697788 countsByYear W556977882016 @default.
- W55697788 countsByYear W556977882017 @default.
- W55697788 countsByYear W556977882019 @default.
- W55697788 countsByYear W556977882020 @default.
- W55697788 countsByYear W556977882022 @default.
- W55697788 countsByYear W556977882023 @default.
- W55697788 crossrefType "journal-article" @default.
- W55697788 hasConcept C112705442 @default.
- W55697788 hasConcept C126322002 @default.
- W55697788 hasConcept C139254425 @default.
- W55697788 hasConcept C159047783 @default.
- W55697788 hasConcept C178790620 @default.
- W55697788 hasConcept C185592680 @default.
- W55697788 hasConcept C203014093 @default.
- W55697788 hasConcept C2522874641 @default.
- W55697788 hasConcept C2776178377 @default.
- W55697788 hasConcept C2776235749 @default.
- W55697788 hasConcept C2776455275 @default.
- W55697788 hasConcept C2776461080 @default.
- W55697788 hasConcept C2776964284 @default.
- W55697788 hasConcept C2780040827 @default.
- W55697788 hasConcept C2781228144 @default.
- W55697788 hasConcept C2909179924 @default.
- W55697788 hasConcept C3020491458 @default.
- W55697788 hasConcept C71924100 @default.
- W55697788 hasConcept C90924648 @default.
- W55697788 hasConcept C98274493 @default.
- W55697788 hasConceptScore W55697788C112705442 @default.
- W55697788 hasConceptScore W55697788C126322002 @default.
- W55697788 hasConceptScore W55697788C139254425 @default.
- W55697788 hasConceptScore W55697788C159047783 @default.
- W55697788 hasConceptScore W55697788C178790620 @default.
- W55697788 hasConceptScore W55697788C185592680 @default.
- W55697788 hasConceptScore W55697788C203014093 @default.
- W55697788 hasConceptScore W55697788C2522874641 @default.
- W55697788 hasConceptScore W55697788C2776178377 @default.
- W55697788 hasConceptScore W55697788C2776235749 @default.
- W55697788 hasConceptScore W55697788C2776455275 @default.
- W55697788 hasConceptScore W55697788C2776461080 @default.
- W55697788 hasConceptScore W55697788C2776964284 @default.
- W55697788 hasConceptScore W55697788C2780040827 @default.
- W55697788 hasConceptScore W55697788C2781228144 @default.
- W55697788 hasConceptScore W55697788C2909179924 @default.
- W55697788 hasConceptScore W55697788C3020491458 @default.
- W55697788 hasConceptScore W55697788C71924100 @default.
- W55697788 hasConceptScore W55697788C90924648 @default.
- W55697788 hasConceptScore W55697788C98274493 @default.
- W55697788 hasLocation W556977881 @default.
- W55697788 hasLocation W556977882 @default.
- W55697788 hasOpenAccess W55697788 @default.
- W55697788 hasPrimaryLocation W556977881 @default.
- W55697788 hasRelatedWork W118298973 @default.
- W55697788 hasRelatedWork W2002416255 @default.
- W55697788 hasRelatedWork W2014171438 @default.
- W55697788 hasRelatedWork W2060842654 @default.
- W55697788 hasRelatedWork W2070354233 @default.
- W55697788 hasRelatedWork W2317554121 @default.
- W55697788 hasRelatedWork W2347142336 @default.
- W55697788 hasRelatedWork W2378588030 @default.
- W55697788 hasRelatedWork W2411773677 @default.
- W55697788 hasRelatedWork W2461318346 @default.
- W55697788 hasVolume "23" @default.
- W55697788 isParatext "false" @default.
- W55697788 isRetracted "false" @default.
- W55697788 magId "55697788" @default.
- W55697788 workType "article" @default.