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- W55734246 abstract "The hemocytes are the cells responsible for the immunity in molluscs. Cytokines, growth factors,etc, present in the soluble fraction of the hemolymph modulate the immune response. Theinflammatory cytokine interleukin-2 (IL-2) induces the synthesis of nitric oxide (NO), responsible foroxidizing processes. In hemocytes of mollusks, the presence of IL-2 induces the synthesis of the threesubunits of the receptor of high affinity, and the subsequent activation of the signaling pathway where the cAMP-dependent protein kinase (PKA) plays the main role, with a secondary role of PKC. In the presence of IL-2, PKA activates NO synthesis through the constitutive enzyme mc-NOS. In winter, the action of PKC on a novel inducible form mw-NOS leads to an increase of the IL-2-induced NO synthesis. According to our studies, this set of metabolic reactions explains the seasonal variations inNO production by hemocytes of Mytilus galloprovincialis. However, after two years of studies, andcoinciding with the Prestige oil spill in November 2002, this effect was cancelled for at least the twoyears following the catastrophe." @default.
- W55734246 created "2016-06-24" @default.
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- W55734246 date "2008-04-29" @default.
- W55734246 modified "2023-09-26" @default.
- W55734246 title "Effects of interleukin-2 on nitric oxide production in molluscan innate immunity" @default.
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