FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W55784880> ?p ?o ?g. }

• W55784880 endingPage "6" @default.
• W55784880 startingPage "1721" @default.
• W55784880 abstract "Alpha2-adrenergic agonists have specific and selective effects on the retina to induce expression of basic fibroblast growth factor and to protect photoreceptors. This work explores the signaling pathway that mediates these effects.Alpha2-adrenergic agonists xylazine and clonidine were administered systemically to male adult Sprague-Dawley rats. The activation state of extracellular signal-regulated kinases (ERKs) in the retina was assessed by immunoblot analysis, using antibodies that specifically recognize the dually phosphorylated forms of p44/p42 ERKs. Localization of phosphorylated ERKs was determined by immunocytochemistry.Intramuscular injection of 6 mg/kg xylazine induced an increase in ERK phosphorylation in the retina within 30 minutes that lasted 3 hours. Xylazine induced ERK phosphorylation at 1 mg/kg and reached a maximum at 10 mg/kg. Injection of clonidine also induced ERK phosphorylation in the retina. Yohimbine, a specific alpha2-adrenergic antagonist, completely prevented the induction of ERK phosphorylation. Immunocytochemical studies showed that the increase in ERK phosphorylation occurred mainly in Müller cells. In the brain, xylazine injection resulted in a decrease in ERK phosphorylation.Our results indicate that systemically administered alpha2-adrenergic agonists selectively activate ERKs in retinal Müller cells. The induced activation of ERKs in Müller cells is probably one of the early events that result in photoreceptor protection. These results also indicate that Müller cells are unique in response to alpha2-adrenergic agonists and imply a role for Müller cells in alpha2-adrenergic agonist-induced photoreceptor protection." @default.
• W55784880 created "2016-06-24" @default.
• W55784880 creator A5008478808 @default.
• W55784880 creator A5031028550 @default.
• W55784880 creator A5042314019 @default.
• W55784880 creator A5068260072 @default.
• W55784880 creator A5081805949 @default.
• W55784880 creator A5088069625 @default.
• W55784880 date "1998-08-01" @default.
• W55784880 modified "2023-10-16" @default.
• W55784880 title "Alpha2-adrenergic agonists selectively activate extracellular signal-regulated kinases in Müller cells in vivo." @default.
• W55784880 cites W1479869774 @default.
• W55784880 cites W1567065545 @default.
• W55784880 cites W1570736076 @default.
• W55784880 cites W1573821584 @default.
• W55784880 cites W1964504843 @default.
• W55784880 cites W1970357302 @default.
• W55784880 cites W1975915718 @default.
• W55784880 cites W1992742082 @default.
• W55784880 cites W1995819749 @default.
• W55784880 cites W2007743820 @default.
• W55784880 cites W2009556803 @default.
• W55784880 cites W2027379276 @default.
• W55784880 cites W2036047243 @default.
• W55784880 cites W2048983596 @default.
• W55784880 cites W2050944466 @default.
• W55784880 cites W2053286013 @default.
• W55784880 cites W2054424607 @default.
• W55784880 cites W2059101000 @default.
• W55784880 cites W2060920490 @default.
• W55784880 cites W2065914444 @default.
• W55784880 cites W2066278140 @default.
• W55784880 cites W2078757969 @default.
• W55784880 cites W2088823687 @default.
• W55784880 cites W2092014913 @default.
• W55784880 cites W2093760408 @default.
• W55784880 cites W2146262948 @default.
• W55784880 cites W2161997958 @default.
• W55784880 cites W2163732263 @default.
• W55784880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9699562" @default.
• W55784880 hasPublicationYear "1998" @default.
• W55784880 type Work @default.
• W55784880 sameAs 55784880 @default.
• W55784880 citedByCount "31" @default.
• W55784880 countsByYear W557848802012 @default.
• W55784880 countsByYear W557848802014 @default.
• W55784880 countsByYear W557848802015 @default.
• W55784880 countsByYear W557848802016 @default.
• W55784880 countsByYear W557848802017 @default.
• W55784880 countsByYear W557848802018 @default.
• W55784880 countsByYear W557848802019 @default.
• W55784880 countsByYear W557848802022 @default.
• W55784880 crossrefType "journal-article" @default.
• W55784880 hasAuthorship W55784880A5008478808 @default.
• W55784880 hasAuthorship W55784880A5031028550 @default.
• W55784880 hasAuthorship W55784880A5042314019 @default.
• W55784880 hasAuthorship W55784880A5068260072 @default.
• W55784880 hasAuthorship W55784880A5081805949 @default.
• W55784880 hasAuthorship W55784880A5088069625 @default.
• W55784880 hasConcept C11960822 @default.
• W55784880 hasConcept C126322002 @default.
• W55784880 hasConcept C134018914 @default.
• W55784880 hasConcept C169760540 @default.
• W55784880 hasConcept C170493617 @default.
• W55784880 hasConcept C184235292 @default.
• W55784880 hasConcept C185592680 @default.
• W55784880 hasConcept C2776885963 @default.
• W55784880 hasConcept C2777676773 @default.
• W55784880 hasConcept C2778938600 @default.
• W55784880 hasConcept C2779591255 @default.
• W55784880 hasConcept C2780795376 @default.
• W55784880 hasConcept C28406088 @default.
• W55784880 hasConcept C57074206 @default.
• W55784880 hasConcept C62478195 @default.
• W55784880 hasConcept C71924100 @default.
• W55784880 hasConcept C86803240 @default.
• W55784880 hasConcept C95444343 @default.
• W55784880 hasConcept C97029542 @default.
• W55784880 hasConceptScore W55784880C11960822 @default.
• W55784880 hasConceptScore W55784880C126322002 @default.
• W55784880 hasConceptScore W55784880C134018914 @default.
• W55784880 hasConceptScore W55784880C169760540 @default.
• W55784880 hasConceptScore W55784880C170493617 @default.
• W55784880 hasConceptScore W55784880C184235292 @default.
• W55784880 hasConceptScore W55784880C185592680 @default.
• W55784880 hasConceptScore W55784880C2776885963 @default.
• W55784880 hasConceptScore W55784880C2777676773 @default.
• W55784880 hasConceptScore W55784880C2778938600 @default.
• W55784880 hasConceptScore W55784880C2779591255 @default.
• W55784880 hasConceptScore W55784880C2780795376 @default.
• W55784880 hasConceptScore W55784880C28406088 @default.
• W55784880 hasConceptScore W55784880C57074206 @default.
• W55784880 hasConceptScore W55784880C62478195 @default.
• W55784880 hasConceptScore W55784880C71924100 @default.
• W55784880 hasConceptScore W55784880C86803240 @default.
• W55784880 hasConceptScore W55784880C95444343 @default.
• W55784880 hasConceptScore W55784880C97029542 @default.
• W55784880 hasIssue "9" @default.

• next