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• W55840464 abstract "Ca 2+ clearance in frog motor nerve terminals was studied by fluorometry of Ca 2+ indicators. Rises in intracellular Ca 2+ ([Ca 2+ ] i ) in nerve terminals induced by tetanic nerve stimulation (100 Hz, 100 or 200 stimuli: Ca 2+ transient) reached a peak or plateau within 6–20 stimuli and decayed at least in three phases with the time constants of 82–87 ms (81–85%), a few seconds (11–12%), and several tens of seconds (less than a few percentage). Blocking both Na/Ca exchangers and Ca 2+ pumps at the cell membrane by external Li + and high external pH (9.0), respectively, increased the time constants of the initial and second decay components with no change in their magnitudes. By contrast, similar effects by Li + alone, but not by high alkaline alone, were seen only on 200 stimuli-induced Ca 2+ transients. Blocking Ca 2+ pumps at Ca 2+ stores by thapsigargin did not affect 100 stimuli-induced Ca 2+ transients but increased the initial decay time constant of 200 stimuli-induced Ca 2+ transients with no change in other parameters. Inhibiting mitochondrial Ca 2+ uptake by carbonyl cyanide m-chlorophenylhydrazone markedly increased the initial and second decay time constants of 100 stimuli-induced Ca 2+ transients and the amplitudes of the second and the slowest components. Plotting the slopes of the decay of 100 stimuli-induced Ca 2+ transients against [Ca 2+ ] i yielded the supralinear [Ca 2+ ] i dependence of Ca 2+ efflux out of the cytosol. Blocking Ca 2+ extrusion or mitochondrial Ca 2+ uptake significantly reduced this [Ca 2+ ] i -dependent Ca 2+ efflux. Thus Ca 2+ -dependent mitochondrial Ca 2+ uptake and plasmalemmal Ca 2+ extrusion clear out a small Ca 2+ load in frog motor nerve terminals, while thapsigargin-sensitive Ca 2+ pump boosts the clearance of a heavy Ca 2+ load. Furthermore, the activity of plasmalemmal Ca 2+ pump and Na/Ca exchanger is complementary to each other with the slight predominance of the latter." @default.
• W55840464 created "2016-06-24" @default.
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• W55840464 date "2002-04-01" @default.
• W55840464 modified "2023-09-26" @default.
• W55840464 title "Ca²⁺-Dependent Ca²⁺Clearance Via Mitochondrial Uptake and Plasmalemmal Extrusion in Frog Motor Nerve Terminals" @default.
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• W55840464 doi "https://doi.org/10.1152/jn.00456.2001" @default.
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