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- W559080 abstract "Up to the present, much attention in cancer research has been focussed on biological changes of malignant cells in vitro when they are treated with hyperthermia. Very little is known how and to what extent the in vivo environment in which these cells are lodged will affect the therapeutic outcome. As a consequence of functional as well as morphological differences of microvascular beds in neoplastic tissue, attempts were made recently to exploit the possibility of enhancing the efficacy of tumor therapy by affecting the microcirculation. Some encouraging results were obtained, and the combination of hyperthermia and conventional tumor treatment began to attract an increasing number of investigators because nutritionally deprived and hypoxic tumor cells appeared to be particularly sensitive to heat (Overgaard and Bichel 1977; Overgaard and Nielsen 1980; Overgaard 1981; Rhee 1984; for a review see Streffer 1985; Vaupel et al. 1983). The extent and etiology of vascular damage in tumors and the possible clinical impact are still subjects of controversy. It is the aim of this paper to:" @default.
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- W559080 date "1988-01-01" @default.
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- W559080 title "Hyperthermia and Microcirculatory Effects of Heat in Animal Tumors" @default.
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- W559080 doi "https://doi.org/10.1007/978-3-642-83263-5_13" @default.
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