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- W55950188 abstract "The first total synthesis of lactodehydrothyrsiferol, a selective inhibitor of protein phosphatase 2A, was accomplished through the application of our electron-transfer-initiated cyclization reaction. Other highlights of our synthetic strategy include a novel method for the formation of 1,1-disubstuted vinyl iodides from a terminal alkyne, a Suzuki-Miyaura cross coupling reaction on a iodinated allylic carbonate, a one pot diepoxidation of a diene to generate two epoxides with opposite stereochemical identities, an asymmetric Nozaki-Hiyama-Kishi reaction, and the selective deoxygenation of a triol. This document will focus on the key epoxide cascade and completion of the synthesis.An oxidative method to form Carbon–Carbon bonds through Carbon–Hydrogen bond cleavage is described herein. Chromene and isochromene both form aromatically stabilized oxocarbenium ions in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The reactivity of these cations was explored with a variety of nucleophiles. In addition, the electronicproperties were altered on the benzopyran ring system to elucidate the substrate scope for this transformation." @default.
- W55950188 created "2016-06-24" @default.
- W55950188 creator A5070599169 @default.
- W55950188 date "2012-10-09" @default.
- W55950188 modified "2023-09-27" @default.
- W55950188 title "An Investigation in Oxidative Cation Formation: The Total Synthesis of Lactodehydrothyrsiferol and Synthetic Application for a Bimolecular Carbon–Carbon Bond Forming Reaction" @default.
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