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• W55962336 abstract "Besides cholinergic hypothesis, it is generally agreed that compromised neuronal energy metabolism may occur in AD. Continuous mild activation of N-methyl-D-aspartate (NMDA) receptors under such conditions may render the cells susceptible to subsequent damage. NMDA antagonist memantine has been shown to be efficient in animal models relevant to human neurodegenerative diseases and dementia. Preclinical studies in vitro and in vivo showed that such a noncontingent activation of this receptor type also leads to impairment of neuronal plasticity (learning), which can be restored by therapeutic concentrations of memantine. These preclinical results were further confirmed in multiple clinical trials. Memantine has been approved by the Food and Drug Administration as the first drug for moderate to severe AD, and is also available in Europe. After the antidementia potential of memantine was widely acknowledged, it became obvious that possible effects of coadministration of this drug with the clinically available AChE inhibitors required investigation. The chapter presents the preclinical and clinical profile of memantine, and discusses the results of animal and human studies on its coadministration with various classes of AChE inhibitors. Because memantine and AChEIs reduce dementia symptoms through distinct mechanisms of action (glutamate antagonism and cholinesterase inhibition, respectively), there is growing interest in investigating whether this combination therapy may improve therapeutic benefit in demented patients. Results of animal studies and the first clinical trials suggest good efficacy and tolerability of the combination of NMDA receptor antagonist and AchEIs. Future clinical research will optimize this approach." @default.
• W55962336 created "2016-06-24" @default.
• W55962336 creator A5067591694 @default.
• W55962336 date "2006-01-01" @default.
• W55962336 modified "2023-09-23" @default.
• W55962336 title "Coadministration of Memantine with Acetylcholinesterase Inhibitors" @default.
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• W55962336 doi "https://doi.org/10.1016/b978-012088523-7/50005-3" @default.
• W55962336 hasPublicationYear "2006" @default.
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