FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W55998601> ?p ?o ?g. }

• W55998601 endingPage "197" @default.
• W55998601 startingPage "192" @default.
• W55998601 abstract "Calvarial bone defects are a common clinical scenario in craniofacial surgery. Numerous approaches are used to reconstruct skull defects, and each possesses its own inherent disadvantages. This fact underscores the opportunity to develop a novel method to repair osseous defects in craniofacial surgery. Recent literature strongly suggests that cell-based therapies in the form of regenerative medicine may be a developing paradigm in reconstructive surgery. Although numerous studies have probed osteoprogenitor cells from mice, few have explored the biology of human cells in the setting of osteogenesis in an equally rigorous manner. This study proposes a nude mouse model of critical-sized calvarial defects to study the in vivo biology of human osteoprogenitor cells. Critical-sized 4.0-mm calvarial defects were created in nude mice (n = 15) with a custom trephine drill bit outfitted to a dental drill handpiece. During the craniotomy, the dura mater was spared from injury. Gross inspection, routine histology, and micro-computed tomographic scanning were performed at 2, 4, 8, and 16 weeks postoperatively. There was no calvarial healing in any of the animals by 16 weeks. The dura mater remained intact in all subjects. Gross, histologic, and radiographic assays confirmed these findings. Although several studies have implanted human osteoprogenitor cells in vivo in various animal models, few have documented the appropriate controls or conditions necessary to support the potential to translate benchtop findings into clinical applications. We propose in this study that the nude mouse critical-sized calvarial defect model will be valuable with increasing investigations with human osteoprogenitor cells." @default.
• W55998601 created "2016-06-24" @default.
• W55998601 creator A5008399962 @default.
• W55998601 creator A5047237212 @default.
• W55998601 creator A5052932481 @default.
• W55998601 creator A5083032143 @default.
• W55998601 creator A5088761931 @default.
• W55998601 date "2008-01-01" @default.
• W55998601 modified "2023-09-26" @default.
• W55998601 title "Applications of an Athymic Nude Mouse Model of Nonhealing Critical-Sized Calvarial Defects" @default.
• W55998601 cites W1964793085 @default.
• W55998601 cites W1972701182 @default.
• W55998601 cites W1979141404 @default.
• W55998601 cites W1980955678 @default.
• W55998601 cites W1994920529 @default.
• W55998601 cites W2022577997 @default.
• W55998601 cites W2037690890 @default.
• W55998601 cites W2051428145 @default.
• W55998601 cites W2068812118 @default.
• W55998601 cites W2069916045 @default.
• W55998601 cites W2072142338 @default.
• W55998601 cites W2082058428 @default.
• W55998601 cites W2087732860 @default.
• W55998601 cites W2102059629 @default.
• W55998601 cites W2119838587 @default.
• W55998601 cites W2119978409 @default.
• W55998601 cites W2125489880 @default.
• W55998601 cites W2136194086 @default.
• W55998601 cites W2150326333 @default.
• W55998601 cites W2156316772 @default.
• W55998601 cites W2173497140 @default.
• W55998601 cites W4239567028 @default.
• W55998601 doi "https://doi.org/10.1097/scs.0b013e31815c93b7" @default.
• W55998601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18216688" @default.
• W55998601 hasPublicationYear "2008" @default.
• W55998601 type Work @default.
• W55998601 sameAs 55998601 @default.
• W55998601 citedByCount "41" @default.
• W55998601 countsByYear W559986012012 @default.
• W55998601 countsByYear W559986012013 @default.
• W55998601 countsByYear W559986012014 @default.
• W55998601 countsByYear W559986012015 @default.
• W55998601 countsByYear W559986012016 @default.
• W55998601 countsByYear W559986012017 @default.
• W55998601 countsByYear W559986012019 @default.
• W55998601 countsByYear W559986012020 @default.
• W55998601 countsByYear W559986012021 @default.
• W55998601 countsByYear W559986012023 @default.
• W55998601 crossrefType "journal-article" @default.
• W55998601 hasAuthorship W55998601A5008399962 @default.
• W55998601 hasAuthorship W55998601A5047237212 @default.
• W55998601 hasAuthorship W55998601A5052932481 @default.
• W55998601 hasAuthorship W55998601A5083032143 @default.
• W55998601 hasAuthorship W55998601A5088761931 @default.
• W55998601 hasConcept C118552586 @default.
• W55998601 hasConcept C141071460 @default.
• W55998601 hasConcept C142724271 @default.
• W55998601 hasConcept C150903083 @default.
• W55998601 hasConcept C202751555 @default.
• W55998601 hasConcept C207001950 @default.
• W55998601 hasConcept C2776232749 @default.
• W55998601 hasConcept C2778043341 @default.
• W55998601 hasConcept C2778871575 @default.
• W55998601 hasConcept C2778987889 @default.
• W55998601 hasConcept C2779300802 @default.
• W55998601 hasConcept C2779918246 @default.
• W55998601 hasConcept C2781245598 @default.
• W55998601 hasConcept C55493867 @default.
• W55998601 hasConcept C71924100 @default.
• W55998601 hasConcept C86803240 @default.
• W55998601 hasConceptScore W55998601C118552586 @default.
• W55998601 hasConceptScore W55998601C141071460 @default.
• W55998601 hasConceptScore W55998601C142724271 @default.
• W55998601 hasConceptScore W55998601C150903083 @default.
• W55998601 hasConceptScore W55998601C202751555 @default.
• W55998601 hasConceptScore W55998601C207001950 @default.
• W55998601 hasConceptScore W55998601C2776232749 @default.
• W55998601 hasConceptScore W55998601C2778043341 @default.
• W55998601 hasConceptScore W55998601C2778871575 @default.
• W55998601 hasConceptScore W55998601C2778987889 @default.
• W55998601 hasConceptScore W55998601C2779300802 @default.
• W55998601 hasConceptScore W55998601C2779918246 @default.
• W55998601 hasConceptScore W55998601C2781245598 @default.
• W55998601 hasConceptScore W55998601C55493867 @default.
• W55998601 hasConceptScore W55998601C71924100 @default.
• W55998601 hasConceptScore W55998601C86803240 @default.
• W55998601 hasIssue "1" @default.
• W55998601 hasLocation W559986011 @default.
• W55998601 hasLocation W559986012 @default.
• W55998601 hasOpenAccess W55998601 @default.
• W55998601 hasPrimaryLocation W559986011 @default.
• W55998601 hasRelatedWork W2002749362 @default.
• W55998601 hasRelatedWork W2009380270 @default.
• W55998601 hasRelatedWork W2043865864 @default.
• W55998601 hasRelatedWork W2047303754 @default.
• W55998601 hasRelatedWork W2062461908 @default.
• W55998601 hasRelatedWork W2080008447 @default.
• W55998601 hasRelatedWork W2085680056 @default.

• next