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- W56032705 abstract "This chapter discusses some of the practical issues of interpretation of the mixed leukocyte reactions (MLR). The MLR can be used to assess histocompatibility differences between two individuals by the recognition of histocompatibility antigens differentially expressed on dendritic cell (DC) of stimulator and responder type. The test also assesses in vitro the ability of DC to initiate primary immune responses either directly or indirectly. The MLR has become the standard functional test to identify DC; DCs are the only cells known to be potent stimulators of primary T cell responses. The experimental assessment of primary stimulation using the MLR will indicate the functional capacity of DC that is in turn affected by many genetic and environmental aspects of the DC. Factors affecting stimulatory capacity of DC include their state of maturity; immature DC may be poor stimulators of allogeneic T cells and may even have tolerogenic effects. The subtype of DC, the types of antigens to which they are exposed and the consequent cytokine profile of the stimulatory DC, all influence the outcome of primary stimulation by DC. Thus, the MLR can be used to assess the basic capacities of DC, including those produced for various forms of immunotherapy, to stimulate primary immune responses." @default.
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- W56032705 date "2005-01-01" @default.
- W56032705 modified "2023-10-13" @default.
- W56032705 title "Mixed Leukocyte Reactions" @default.
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- W56032705 doi "https://doi.org/10.1016/b978-012455900-4/50292-0" @default.
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