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• W5603822 endingPage "138" @default.
• W5603822 startingPage "111" @default.
• W5603822 abstract "Legionella pneumophila, the agent responsible for Legionnaire’s disease, is a facultative intracellular pathogen that can replicate within protozoa and macrophages. Protozoa are considered to play a central role in the pathogenesis and ecology of L. pneumophila. In humans, L. pneumophila reaches the lungs, where it is ingested by alveolar macrophages. Unlike phagosomes containing inert particles or avirulent bacteria, the L. pneumophila-containing vacuoles avoid fusion with lysosomes, recruiting rough endoplasmic reticulum and mitochondria. The formation of this specialized vacuole is directed by the type IV secretion system encoded by the dot/icm genes in mammalian and protozoan cells. Killing of mammalian cells by L. pneumophila has been proposed to occur through induction of apoptosis during the early stages of the infection. A rapid induction of necrosis by L. pneumophila also occurs upon entry into the post-exponential phase of growth within both macrophages and protozoa, when the bacteria become cytotoxic. Before the lysis of the mammalian or protozoan plasma membrane, the bacteria egress into the cytoplasm. In vivo, clearance of Legionella from the lungs depends on the host production of IFN-γ in A/J mice, while in BALB/c mice IFN-γ is not produced. Intracellular replication of L. pneumophila is inhibited in IFN-γ-activated mouse and human primary macrophages. Both antigen-specific humoral and cell-mediated immune responses are induced during Legionella infection. Although Legionella-specific antibodies are produced during human or murine infection, acquired cell-mediated immune response is believed to play a stronger role in Legionella clearance. Both macrophages and DCs are able to present microbial antigens on major histocompatibility class I and class II molecules, which stimulate antigen-specific T-cell response. Identification of antigens and determination of vesicular trafficking mechanisms involved in processing and presentation remain to be understood in greater detail.KeywordsSecretion SystemIntracellular GrowthIntracellular ReplicationAcanthamoeba CastellaniiPhagosomal MembraneThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W5603822 created "2016-06-24" @default.
• W5603822 creator A5018120874 @default.
• W5603822 creator A5019512112 @default.
• W5603822 creator A5040687308 @default.
• W5603822 creator A5059037119 @default.
• W5603822 date "2007-01-18" @default.
• W5603822 modified "2023-10-14" @default.
• W5603822 title "Legionnaires’ disease and its agent Legionella pneumophila" @default.
• W5603822 cites W1489373212 @default.
• W5603822 cites W1496030547 @default.
• W5603822 cites W1512057284 @default.
• W5603822 cites W1512432351 @default.
• W5603822 cites W1516157366 @default.
• W5603822 cites W1528950689 @default.
• W5603822 cites W1540043221 @default.
• W5603822 cites W1562197221 @default.
• W5603822 cites W1563856555 @default.
• W5603822 cites W1749919633 @default.
• W5603822 cites W1826903259 @default.
• W5603822 cites W1844221752 @default.
• W5603822 cites W1865722670 @default.
• W5603822 cites W1878766934 @default.
• W5603822 cites W1891680216 @default.
• W5603822 cites W1917574459 @default.
• W5603822 cites W1923100104 @default.
• W5603822 cites W1931230038 @default.
• W5603822 cites W1936395475 @default.
• W5603822 cites W1946493814 @default.
• W5603822 cites W1958291016 @default.
• W5603822 cites W1970960991 @default.
• W5603822 cites W1971857640 @default.
• W5603822 cites W1972093499 @default.
• W5603822 cites W1975678678 @default.
• W5603822 cites W1978891891 @default.
• W5603822 cites W1980076571 @default.
• W5603822 cites W1981783746 @default.
• W5603822 cites W1982001427 @default.
• W5603822 cites W1986997900 @default.
• W5603822 cites W1987587550 @default.
• W5603822 cites W1989169704 @default.
• W5603822 cites W1991450517 @default.
• W5603822 cites W1992629559 @default.
• W5603822 cites W1994784756 @default.
• W5603822 cites W1999924463 @default.
• W5603822 cites W2000957550 @default.
• W5603822 cites W2007412334 @default.
• W5603822 cites W2008034134 @default.
• W5603822 cites W2008349157 @default.
• W5603822 cites W2011255441 @default.
• W5603822 cites W2016746117 @default.
• W5603822 cites W2021387811 @default.
• W5603822 cites W2021750140 @default.
• W5603822 cites W2021878136 @default.
• W5603822 cites W2024746774 @default.
• W5603822 cites W2028498044 @default.
• W5603822 cites W2030606199 @default.
• W5603822 cites W2031161780 @default.
• W5603822 cites W2035842134 @default.
• W5603822 cites W2036431012 @default.
• W5603822 cites W2044352824 @default.
• W5603822 cites W2045789066 @default.
• W5603822 cites W2046599852 @default.
• W5603822 cites W2047034243 @default.
• W5603822 cites W2048605572 @default.
• W5603822 cites W2050085375 @default.
• W5603822 cites W2053350257 @default.
• W5603822 cites W2054130105 @default.
• W5603822 cites W2054323226 @default.
• W5603822 cites W2057123194 @default.
• W5603822 cites W2057927518 @default.
• W5603822 cites W2058175344 @default.
• W5603822 cites W2060328411 @default.
• W5603822 cites W2060702462 @default.
• W5603822 cites W2066760739 @default.
• W5603822 cites W2066974855 @default.
• W5603822 cites W2067402200 @default.
• W5603822 cites W2071905511 @default.
• W5603822 cites W2072329960 @default.
• W5603822 cites W2075232887 @default.
• W5603822 cites W2075821783 @default.
• W5603822 cites W2079580539 @default.
• W5603822 cites W2080156773 @default.
• W5603822 cites W2080323543 @default.
• W5603822 cites W2080563387 @default.
• W5603822 cites W2085753387 @default.
• W5603822 cites W2086254443 @default.
• W5603822 cites W2087399793 @default.
• W5603822 cites W2087664087 @default.
• W5603822 cites W2093725577 @default.
• W5603822 cites W2094198843 @default.
• W5603822 cites W2096466814 @default.
• W5603822 cites W2096915882 @default.
• W5603822 cites W2100239296 @default.
• W5603822 cites W2100509550 @default.
• W5603822 cites W2100535328 @default.
• W5603822 cites W2104416424 @default.
• W5603822 cites W2104752214 @default.

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