FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W56077963> ?p ?o ?g. }

• W56077963 abstract "Event Abstract Back to Event Dissection of apoptotic events and pathways induced by MSG in newborn rat retina Viktoria Denes1*, Monika Lakk1 and Robert Gabriel1 1 Department of Experimental Zoology and Neurobiology, University of Pecs, Hungary Excitotoxicity caused by excessive glutamate level in neuronal tissues occurs in a large number of diseases. Monosodium glutamate (MSG) has been widely used not only to mimic the toxic effects of glutamate but to probe neurodegeneration mechanisms. It has been reported that overexciting NMDA receptors by MSG induces apoptosis in vivo and in vitro. However, the subcellular effects of MSG on retina in vivo have not been adequately studied yet. Here we provided an analysis of the apoptotic events induced by MSG using immunoblot, immunocytochemistry and DNA detection. We focused on the family of caspases that processes programmed cell death. Levels of one initiator (caspase 9) and three effector caspases (caspase 3, 6, 7) were examined at four time points after subcutaneous injection of 2 mg/g bodyweight MSG in newborn rats. We found a significant elevation of active Casp 9 level in 3 hours followed by a marked increase at 6 hours. The highest level of the active Casp 3 was also detected in 6 hours. Since Casp 3 activates Casp 6, levels of the active Casp 6 accompanied Casp 3. The amounts of Casp 7 changed with the same dynamics. Consistent with the immunoblot, the most Casp 3 immunopositive cells were revealed in retinal layers in 6 hours. The apoptotic DNA ladder appeared only in 12 and 24 hours. It seems that subcutaneous addition of MSG rapidly recruits the mitochondrial pathways of apoptosis resulting in the activation of Casp 9, consequently, activation of Casp 3 and 6. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Pathophysiology and neurology - degenerative disorders Citation: Denes V, Lakk M and Gabriel R (2009). Dissection of apoptotic events and pathways induced by MSG in newborn rat retina. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.146 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Mar 2009; Published Online: 05 Mar 2009. * Correspondence: Viktoria Denes, Department of Experimental Zoology and Neurobiology, University of Pecs, Pecs, Hungary, vdenes@gamma.ttk.pte.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Viktoria Denes Monika Lakk Robert Gabriel Google Viktoria Denes Monika Lakk Robert Gabriel Google Scholar Viktoria Denes Monika Lakk Robert Gabriel PubMed Viktoria Denes Monika Lakk Robert Gabriel Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
• W56077963 created "2016-06-24" @default.
• W56077963 creator A5057220825 @default.
• W56077963 date "2009-01-01" @default.
• W56077963 modified "2023-09-26" @default.
• W56077963 title "Dissection of apoptotic events and pathways induced by MSG in newborn rat retina" @default.
• W56077963 doi "https://doi.org/10.3389/conf.neuro.01.2009.04.146" @default.
• W56077963 hasPublicationYear "2009" @default.
• W56077963 type Work @default.
• W56077963 sameAs 56077963 @default.
• W56077963 citedByCount "0" @default.
• W56077963 crossrefType "journal-article" @default.
• W56077963 hasAuthorship W56077963A5057220825 @default.
• W56077963 hasBestOaLocation W560779631 @default.
• W56077963 hasConcept C126322002 @default.
• W56077963 hasConcept C153911025 @default.
• W56077963 hasConcept C170493617 @default.
• W56077963 hasConcept C18051474 @default.
• W56077963 hasConcept C190283241 @default.
• W56077963 hasConcept C207001950 @default.
• W56077963 hasConcept C2776925932 @default.
• W56077963 hasConcept C2779134260 @default.
• W56077963 hasConcept C2781012912 @default.
• W56077963 hasConcept C31573885 @default.
• W56077963 hasConcept C47701112 @default.
• W56077963 hasConcept C54355233 @default.
• W56077963 hasConcept C55493867 @default.
• W56077963 hasConcept C61174792 @default.
• W56077963 hasConcept C66153294 @default.
• W56077963 hasConcept C71924100 @default.
• W56077963 hasConcept C86803240 @default.
• W56077963 hasConcept C95444343 @default.
• W56077963 hasConcept C98424977 @default.
• W56077963 hasConceptScore W56077963C126322002 @default.
• W56077963 hasConceptScore W56077963C153911025 @default.
• W56077963 hasConceptScore W56077963C170493617 @default.
• W56077963 hasConceptScore W56077963C18051474 @default.
• W56077963 hasConceptScore W56077963C190283241 @default.
• W56077963 hasConceptScore W56077963C207001950 @default.
• W56077963 hasConceptScore W56077963C2776925932 @default.
• W56077963 hasConceptScore W56077963C2779134260 @default.
• W56077963 hasConceptScore W56077963C2781012912 @default.
• W56077963 hasConceptScore W56077963C31573885 @default.
• W56077963 hasConceptScore W56077963C47701112 @default.
• W56077963 hasConceptScore W56077963C54355233 @default.
• W56077963 hasConceptScore W56077963C55493867 @default.
• W56077963 hasConceptScore W56077963C61174792 @default.
• W56077963 hasConceptScore W56077963C66153294 @default.
• W56077963 hasConceptScore W56077963C71924100 @default.
• W56077963 hasConceptScore W56077963C86803240 @default.
• W56077963 hasConceptScore W56077963C95444343 @default.
• W56077963 hasConceptScore W56077963C98424977 @default.
• W56077963 hasLocation W560779631 @default.
• W56077963 hasOpenAccess W56077963 @default.
• W56077963 hasPrimaryLocation W560779631 @default.
• W56077963 hasRelatedWork W1967264415 @default.
• W56077963 hasRelatedWork W19916217 @default.
• W56077963 hasRelatedWork W2031840568 @default.
• W56077963 hasRelatedWork W2074148448 @default.
• W56077963 hasRelatedWork W2092116220 @default.
• W56077963 hasRelatedWork W2145626047 @default.
• W56077963 hasRelatedWork W2151098840 @default.
• W56077963 hasRelatedWork W2594560619 @default.
• W56077963 hasRelatedWork W2931523797 @default.
• W56077963 hasRelatedWork W4220681557 @default.
• W56077963 hasVolume "3" @default.
• W56077963 isParatext "false" @default.
• W56077963 isRetracted "false" @default.
• W56077963 magId "56077963" @default.
• W56077963 workType "article" @default.