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- W56082306 abstract "Objective To explore the diagnostic value of dual-time-point ^18F-FDG PET-CT imaging in detecting hilar and mediastinal lymph node metastasis in non - small - cell lung cancer （ NSCLC ） . Methods Forty-six patients with NSCLC underwent standard whole body single-time ISF-FDG PET-CT scans and a delayed imaging for the thorax alone before surgery, meanwhile, the standard uptake value （SUV） and retention index （RI） were calculated. Results A total number of 584 lymph nodes were excised in the 46 patients. Of these, 134 metastatic lymph nodes were pathologically confirmed in 31 patients. There were 189 lymph nodes detected and suspected to be metastatic by standard single-time ^18F-FDG PET-CT imaging, and 161 by dual-time-point imaging. Therefore, the sensitivity, specificity, diagnostic accuracy, positive predictive value and negative predictive value in the detection of hilar and mediastinal lymph node metastasis were 87.3%, 84.0%, 84.8%, 61.9% and 95.7% by standard single-time ^18F-FDG PET-CT imaging, versus 94.8%, 92.2%, 92.8%, 78.9% and 98. 1%, respectively, by dual-time-point imaging. There was a statistically significant difference in the detection of lymph node metastasis between the standard singletime imaging and dual-time-point ^18F-FDG PET-CT imaging. Conclusion Dual-time-point ^18F-FDG PETCT imaging is more sensitive, specific and accurate than standard single-time ^18F-FDG PET-CT imaging in the detection of hilar and mediastinal lymph node metastasis, and may provide more information for diagnosis, staging and treatment of non-small cell lung cancer.Key words: FDG PET-CT; Non-small-cell lung cancer; Dual-time-point imaging; Lymphatic metastasis" @default.
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- W56082306 date "2008-04-01" @default.
- W56082306 modified "2023-09-24" @default.
- W56082306 title "[Significance of dual-time-point 18F-FDG PET imaging in evaluation of hilar and mediastinal lymph node metastasis in non-small-cell lung cancer]." @default.
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