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- W560938566 abstract "It is now well established that hypercholesterolaemia and more particularly an increased LDL-cholesterol serum level is a major risk factor for coronary artery disease. The first approach to lowering cholesterol levels is dietary modifications. Dietary recommendation include a lower fat intake, specifically that of saturated fats (lipids less than 30% of total calories and saturated fat calories less than 10%) and a moderate dietary cholesterol intake (inferior to 300 mg/d). However, it is not easy to change lifestyle over a long term period. New ideas are needed to improve the cholesterol-lowering effect of dietary interventions. Since the 1950’s, it has been known that plant sterols, called phytosterols, lower cholesterol levels in animals and humans. Plant sterols, although structurally related to cholesterol, are not absorbed to any significant degree in humans. In fact, when ingested with a typical diet, plant sterols and their saturated derivatives, plant stanols, interfere with cholesterol absorption in the human intestine, causing reduction in plasma total and low-density-lipoprotein (LDL) cholesterol levels of up to 14%. A tremendous amount of research has been conducted in the field of plant sterols and plant stanols in order to determine the optimal method way of administration." @default.
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- W560938566 date "2000-11-21" @default.
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- W560938566 title "Phytosterols: a new dietetic approach to the treatment of hypercholesterolaemia" @default.
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