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- W56095904 abstract "Retinoids have anti-tumor activity in several pre-malignant and malignant conditions, but considering the research effort and development of new retinoids, they have failed to fulfill their early promise as general anti-cancer agents. There are few cancers that respond well to retinoid monotherapy such as promyelocytic leukemia, but retinoids may be effective in the treatment of several other malignancies in combination with agents such as cytokines. The identification of different nuclear retinoid receptors and several retinoid responsive genes has increased dramatically our understanding of the signaling mechanisms involved, and why some cell lines do not respond to retinoids due to loss of receptors or aberrations in their signaling pathways. In many tumor cell types retinoids induce differentiation, inhibit growth, angiogenesis and invasion, modulate adhesive interactions and host immune responses, or induce apoptosis. This review will focus upon the effects of retinoids on the various steps involved in the development and progression of a tumor from in situ to invasive to metastatic lesions. Further research will undoubtedly increase our understanding of the retinoid signaling pathways, and possibly the interaction of retinoid receptors with other types of receptors, and the identification of retinoid responsive elements on many more genes. Such information may enable the targeting of retinoids to predicted responsive tumors." @default.
- W56095904 created "2016-06-24" @default.
- W56095904 creator A5054901729 @default.
- W56095904 date "1997-01-01" @default.
- W56095904 modified "2023-09-23" @default.
- W56095904 title "Retinoids in Tumor Cell Adhesion, Invasion, and Metastasis" @default.
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- W56095904 doi "https://doi.org/10.1016/s1569-2590(08)60057-9" @default.
- W56095904 hasPublicationYear "1997" @default.
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