Matches in SemOpenAlex for { <https://semopenalex.org/work/W56107335> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W56107335 endingPage "8" @default.
- W56107335 startingPage "482" @default.
- W56107335 abstract "It is important to exclude germ line mutation in cases of unilateral retinoblastoma(RB) to estimate hereditary or possible secondary cancer. We investigated whether genetic diagnosis is feasible in a health check screening program.Five patients with RB had surgery for enucleation in Keio University Hospital. Tumor cells from enucleated eyes and lymphocytes representing systemic cells were collected and analyzed genetically by fluorescence in situ hybridization(FISH) and restriction fragment length polymorphism (RFLP).One out of three unilateral RB cases could be diagnosed as non-hereditary by the finding of no copies of the RB gene in the tumor cells using the FISH method and no signal in the RFLP method. A decrease of signal in tumor cells to less than 50% in the RFLP method was observed in another case of unilateral RB that seemed to be non-hereditary, but the case ultimately could not be diagnosed as non-hereditary because polycopies were found in the FISH method. No abnormality in tumor cells could be found in another unilateral case or in systemic cells of two bilateral cases.A combination of FISH and RFLP methods can be used to diagnose some cases of RB as non-hereditary." @default.
- W56107335 created "2016-06-24" @default.
- W56107335 creator A5003537669 @default.
- W56107335 creator A5009964528 @default.
- W56107335 creator A5013537921 @default.
- W56107335 creator A5043926453 @default.
- W56107335 creator A5046272183 @default.
- W56107335 creator A5069758462 @default.
- W56107335 creator A5079694903 @default.
- W56107335 creator A5088798513 @default.
- W56107335 date "2004-08-01" @default.
- W56107335 modified "2023-09-26" @default.
- W56107335 title "[Genetic diagnosis of retinoblastoma by a combination of fluorescence in situ hybridization and restriction fragment length polymorphism]." @default.
- W56107335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15457990" @default.
- W56107335 hasPublicationYear "2004" @default.
- W56107335 type Work @default.
- W56107335 sameAs 56107335 @default.
- W56107335 citedByCount "0" @default.
- W56107335 crossrefType "journal-article" @default.
- W56107335 hasAuthorship W56107335A5003537669 @default.
- W56107335 hasAuthorship W56107335A5009964528 @default.
- W56107335 hasAuthorship W56107335A5013537921 @default.
- W56107335 hasAuthorship W56107335A5043926453 @default.
- W56107335 hasAuthorship W56107335A5046272183 @default.
- W56107335 hasAuthorship W56107335A5069758462 @default.
- W56107335 hasAuthorship W56107335A5079694903 @default.
- W56107335 hasAuthorship W56107335A5088798513 @default.
- W56107335 hasConcept C104317684 @default.
- W56107335 hasConcept C135763542 @default.
- W56107335 hasConcept C153911025 @default.
- W56107335 hasConcept C168007829 @default.
- W56107335 hasConcept C188261085 @default.
- W56107335 hasConcept C2776577112 @default.
- W56107335 hasConcept C2777542201 @default.
- W56107335 hasConcept C30481170 @default.
- W56107335 hasConcept C54355233 @default.
- W56107335 hasConcept C71924100 @default.
- W56107335 hasConcept C86803240 @default.
- W56107335 hasConceptScore W56107335C104317684 @default.
- W56107335 hasConceptScore W56107335C135763542 @default.
- W56107335 hasConceptScore W56107335C153911025 @default.
- W56107335 hasConceptScore W56107335C168007829 @default.
- W56107335 hasConceptScore W56107335C188261085 @default.
- W56107335 hasConceptScore W56107335C2776577112 @default.
- W56107335 hasConceptScore W56107335C2777542201 @default.
- W56107335 hasConceptScore W56107335C30481170 @default.
- W56107335 hasConceptScore W56107335C54355233 @default.
- W56107335 hasConceptScore W56107335C71924100 @default.
- W56107335 hasConceptScore W56107335C86803240 @default.
- W56107335 hasIssue "8" @default.
- W56107335 hasLocation W561073351 @default.
- W56107335 hasOpenAccess W56107335 @default.
- W56107335 hasPrimaryLocation W561073351 @default.
- W56107335 hasRelatedWork W2026283018 @default.
- W56107335 hasRelatedWork W2041597883 @default.
- W56107335 hasRelatedWork W2049907875 @default.
- W56107335 hasRelatedWork W2051837221 @default.
- W56107335 hasRelatedWork W2065304488 @default.
- W56107335 hasRelatedWork W2078416547 @default.
- W56107335 hasRelatedWork W2084193824 @default.
- W56107335 hasRelatedWork W2116864152 @default.
- W56107335 hasRelatedWork W2152472434 @default.
- W56107335 hasRelatedWork W2153654293 @default.
- W56107335 hasRelatedWork W2159498354 @default.
- W56107335 hasRelatedWork W2165981075 @default.
- W56107335 hasRelatedWork W2167503138 @default.
- W56107335 hasRelatedWork W2185905315 @default.
- W56107335 hasRelatedWork W2406223392 @default.
- W56107335 hasRelatedWork W2414667945 @default.
- W56107335 hasRelatedWork W2419422156 @default.
- W56107335 hasRelatedWork W2440675992 @default.
- W56107335 hasRelatedWork W3196011244 @default.
- W56107335 hasRelatedWork W1543249073 @default.
- W56107335 hasVolume "108" @default.
- W56107335 isParatext "false" @default.
- W56107335 isRetracted "false" @default.
- W56107335 magId "56107335" @default.
- W56107335 workType "article" @default.