Matches in SemOpenAlex for { <https://semopenalex.org/work/W56130107> ?p ?o ?g. }
- W56130107 endingPage "399" @default.
- W56130107 startingPage "395" @default.
- W56130107 abstract "Origin-recognition complex (ORC), a candidate initiator of chromosomal DNA replication in eukaryotes, shares certain biochemical characteristics with DnaA, the initiator of chromosomal DNA replication in prokaryotes. These similarities include origin-specific DNA binding, ATP binding and ATPase activity. DnaA interacts with acidic phospholipids, such as cardiolipin, and its activity is regulated by these phospholipids. In this study, we examined whether Saccharomyces cerevisiae ORC also interacts with phospholipids. Among the various phospholipids tested, ORC was found to bind specifically to cardiolipin. This binding was inhibited by excess concentrations of salts but unaffected by ATP, adenosine 5′-[γ-thio]triphosphate or the origin DNA. Cardiolipin weakly inhibited the ATP-binding activity of ORC, whereas it strongly inhibited ORC binding to origin DNA. Acidic phospholipids other than cardiolipin (phosphatidylglycerol and phosphatidylinositol) weakly inhibited ORC binding to origin DNA. Furthermore, total phospholipids extracted from yeast nuclear membranes inhibited ORC binding to origin DNA. We consider that phospholipids may modulate initiation of DNA replication in eukaryotes in a similar manner to that found in prokaryotes." @default.
- W56130107 created "2016-06-24" @default.
- W56130107 creator A5004738239 @default.
- W56130107 creator A5022889233 @default.
- W56130107 creator A5037469150 @default.
- W56130107 creator A5051063317 @default.
- W56130107 creator A5057719096 @default.
- W56130107 creator A5067327271 @default.
- W56130107 creator A5069123778 @default.
- W56130107 date "2002-02-22" @default.
- W56130107 modified "2023-09-23" @default.
- W56130107 title "Inhibitory effects of acidic phospholipids on the binding of origin-recognition complex to origin DNA" @default.
- W56130107 cites W1502935855 @default.
- W56130107 cites W1506251534 @default.
- W56130107 cites W1530704664 @default.
- W56130107 cites W1537545744 @default.
- W56130107 cites W1968863900 @default.
- W56130107 cites W1977422610 @default.
- W56130107 cites W1977796033 @default.
- W56130107 cites W1983178225 @default.
- W56130107 cites W1985481802 @default.
- W56130107 cites W2037161301 @default.
- W56130107 cites W2046503168 @default.
- W56130107 cites W2048244879 @default.
- W56130107 cites W2049231478 @default.
- W56130107 cites W2054118983 @default.
- W56130107 cites W2054881891 @default.
- W56130107 cites W2056022940 @default.
- W56130107 cites W2059594509 @default.
- W56130107 cites W2061135731 @default.
- W56130107 cites W2068135053 @default.
- W56130107 cites W2080183231 @default.
- W56130107 cites W2093112544 @default.
- W56130107 cites W2100729931 @default.
- W56130107 cites W2103697688 @default.
- W56130107 cites W2109423665 @default.
- W56130107 cites W2139316119 @default.
- W56130107 cites W2151359441 @default.
- W56130107 cites W2159589446 @default.
- W56130107 cites W2170085122 @default.
- W56130107 doi "https://doi.org/10.1042/bj3620395" @default.
- W56130107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1222400" @default.
- W56130107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11853548" @default.
- W56130107 hasPublicationYear "2002" @default.
- W56130107 type Work @default.
- W56130107 sameAs 56130107 @default.
- W56130107 citedByCount "8" @default.
- W56130107 crossrefType "journal-article" @default.
- W56130107 hasAuthorship W56130107A5004738239 @default.
- W56130107 hasAuthorship W56130107A5022889233 @default.
- W56130107 hasAuthorship W56130107A5037469150 @default.
- W56130107 hasAuthorship W56130107A5051063317 @default.
- W56130107 hasAuthorship W56130107A5057719096 @default.
- W56130107 hasAuthorship W56130107A5067327271 @default.
- W56130107 hasAuthorship W56130107A5069123778 @default.
- W56130107 hasBestOaLocation W561301072 @default.
- W56130107 hasConcept C107827726 @default.
- W56130107 hasConcept C151158763 @default.
- W56130107 hasConcept C2776330855 @default.
- W56130107 hasConcept C2777576037 @default.
- W56130107 hasConcept C2778918659 @default.
- W56130107 hasConcept C2779222958 @default.
- W56130107 hasConcept C2780726299 @default.
- W56130107 hasConcept C2781302388 @default.
- W56130107 hasConcept C41625074 @default.
- W56130107 hasConcept C552990157 @default.
- W56130107 hasConcept C55493867 @default.
- W56130107 hasConcept C73573662 @default.
- W56130107 hasConcept C86803240 @default.
- W56130107 hasConcept C95444343 @default.
- W56130107 hasConcept C98086919 @default.
- W56130107 hasConceptScore W56130107C107827726 @default.
- W56130107 hasConceptScore W56130107C151158763 @default.
- W56130107 hasConceptScore W56130107C2776330855 @default.
- W56130107 hasConceptScore W56130107C2777576037 @default.
- W56130107 hasConceptScore W56130107C2778918659 @default.
- W56130107 hasConceptScore W56130107C2779222958 @default.
- W56130107 hasConceptScore W56130107C2780726299 @default.
- W56130107 hasConceptScore W56130107C2781302388 @default.
- W56130107 hasConceptScore W56130107C41625074 @default.
- W56130107 hasConceptScore W56130107C552990157 @default.
- W56130107 hasConceptScore W56130107C55493867 @default.
- W56130107 hasConceptScore W56130107C73573662 @default.
- W56130107 hasConceptScore W56130107C86803240 @default.
- W56130107 hasConceptScore W56130107C95444343 @default.
- W56130107 hasConceptScore W56130107C98086919 @default.
- W56130107 hasIssue "2" @default.
- W56130107 hasLocation W561301071 @default.
- W56130107 hasLocation W561301072 @default.
- W56130107 hasLocation W561301073 @default.
- W56130107 hasLocation W561301074 @default.
- W56130107 hasOpenAccess W56130107 @default.
- W56130107 hasPrimaryLocation W561301071 @default.
- W56130107 hasRelatedWork W1484032993 @default.
- W56130107 hasRelatedWork W1493567759 @default.
- W56130107 hasRelatedWork W1909766436 @default.
- W56130107 hasRelatedWork W1970553847 @default.
- W56130107 hasRelatedWork W2062433889 @default.