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- W56147688 endingPage "121" @default.
- W56147688 startingPage "103" @default.
- W56147688 abstract "Abstract Serotonin (5-hydroxytryptamine; 5-HT), along with its receptors, is one of the oldest molecular devices assuming intercellular communication, being present as soon as simple nervous systems appeared during evolution. 5-HT receptors (7 classes, 5-HT 1 to 5-HT 7 , coded by 17 different genes) are G protein-coupled receptors (GPCR) except for 5-HT 3 receptors, which are ionic channels. Splicing and editing add to the diversity of 5-HT receptors. They were first defined on a pharmacological basis and then on a gene structural basis, but the concordance between these two classifications is remarkable. The complexity of signaling events, including G protein-independent signaling of the GPCR classes, is not yet fully understood, and underscores the physiological importance of 5-HT. 5-HT receptors are associated with a large number of proteins involved in their localization, traffic and the fine-tuning signaling. Homodimerization and heterodimerization of 5-HT receptors with other GPCRs but also ligand-directed signaling (signaling dependent on the ligand and not only on the receptor) add to the complexity. Finally, 5-HT receptors are the targets of many therapeutic drugs on the market, in development and yet to be developed." @default.
- W56147688 created "2016-06-24" @default.
- W56147688 creator A5000300292 @default.
- W56147688 creator A5008089947 @default.
- W56147688 creator A5045863654 @default.
- W56147688 creator A5062205416 @default.
- W56147688 date "2010-01-01" @default.
- W56147688 modified "2023-10-03" @default.
- W56147688 title "Classification and Signaling Characteristics of 5-HT Receptors" @default.
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